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Tumor Microenvironment Exosomes and Extracellular Vesicles Breast Cancer Metastasis Bone Metastasis Metastatic Renal Cell Carcinoma Lymph node metastasis Mesothelioma Hematological Malignancies Thyroid Cancer Liquid Biopsies Early Diagnosis Lung Cancer Brain Tumors Lymphoma Oncolytic Virus Cervical Cancer Cancer Stem Cells

Topic: Bone Microenvironment and Bone Metastasis

A special issue of Journal of Cancer Metastasis and Treatment

ISSN 2454-2857 (Online), ISSN 2394-4722 (Print)

Submission deadline: 30 Sep 2021

Guest Editor(s)

  • Prof. Robert Coleman
    Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.

    Website | E-mail

Special Issue Introduction

Metastasis is a highly complex albeit relatively inefficient process, with bone the dominant site for involvement across a range of solid tumours. The multiple interactions within the bone microenvironment from the earliest phases when establishment of the pre-metastatic niche occurs, through tumour cell homing, dormancy and subsequent reactivation leading to overt metastasis are of great interest and our knowledge from ever more sophisticated preclinical models is unraveling the complex biological processes involved. For several decades there has been interest in the potential of bone-targeted agents, through their profound effects on bone physiology, to modify the process of metastasis and have effects on important disease outcomes such as recurrence and survival. This hypothesis has been the focus of extensive laboratory and clinical research in a several tumour types with variable results. This Special Issue aims to bring together the recent progress made from across laboratory and clinical settings and set out challenges for future research and clinical trials to try and minimise the enormous clinical burden associated with metastatic bone disease.

Areas for consideration include:
Bone metastases (pathophysiology, epidemiology, diagnostics, clinical features, prevention, treatment).
Preclinical models of metastasis.
Bone microenvironment in cancer (stem cell, bone cell and cancer interactions).
Bone targeted therapy (pharmacology, therapeutic targets, drug development, clinical trials).
Bone imaging (clinical and animal, skeletal interventional radiology).
Bone biomarkers (clinical and translational applications).

Submission Deadline

30 Sep 2021

Submission Information

For Author Instructions, please refer to
For Online Submission, please login at
Submission Deadline: 30 Sep 2021
Contacts: Olivia Zhao, Assistant Editor,

Published Articles

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