Special Issue Introduction
Dear Cancer Scientists,
I am John Pawelek, PhD. As Guest Editor for the Journal of Cancer Metastasis and Treatment
, I would like to invite you to contribute an article to the journal.
While it is well known that primary tumors arise due to mutations that cause unrestricted cell division, until recently the mechanism for metastasis has remained a mystery. In 1911 a German gynecologist, Prof. Otto Aichel, proposed that metastasis might result from the fusion and hybridization between motile leukocytes such as macrophages, and cancer cells. The result is the formation of an entirely new cell that retains the unrestricted cell division of the cancer cell while expressing the macrophage traits of chemotactic motility and homing to lymph nodes and distant tissues and organs, that is, a metastatic cell. Now several groups, including our own, have shown that Aichel was correct and that formation of metastatic hybrids is the major, if not sole mechanism for metastasis (LaBerge et al. Leukocyte–Cancer Cell Fusion - Genesis of a Deadly Journey. Cells, 2019. PMID: 30781683 PMCID: PMC6406780DOI: 10.3390/cells8020170). I am encouraging cancer scientists around the world to submit articles on all aspects of this topic the special issue "Genetic Insights into Cancer Metastasis ". The submission deadline is July 31, 2021 and the submission website is:
Thank you very much for considering this invitation.