- Assoc. Prof. Ching-Shu Lai
- National Kaohsiung University of Science and Technology, Kaohsiung, Taiwan.
- Assoc. Prof. Wei-Lun Hung
- School of Food Safety,Taipei Medical University, Taipei, Taiwan.
Special Issue Introduction
Cancer is a major health problem and a leading cause of death that involves abnormal growth of cells with the potential to invade and metastasize to other part of the body. Cancer chemoprevention is defined as the use of agents to repeal, repress or thwart the cancer growth to malignancy. Numerous natural, synthetic or biologic chemical agents are able to interfere with different steps of carcinogenesis. Many in vitro and animal studies have demonstrated that chemopreventive agents can block or reverse the promotion stage of multistage carcinogenesis or retard the progression of precancerous cell into malignant ones. Besides, numerous cell-signaling pathways associated with cell proliferation and differentiation involved in anticarcinogenic actions of these agents have been identified. Importantly, emerging data have supported that epigenetic regulation is a promising strategy in cancer chemoprevention through altering DNA methylation and histone modification, modulating miRNA expression, recovering circadian rhythm, and modifying gut microbiota.
Plant-derived phytochemicals are a dominant source of chemopreventive agents. In the body, the bioaccessibility, bioavailability and metabolism of these natural compounds may greatly affect their role in cancer prevention. Besides, the combined use of the chemopreventive agents, which possess different mechanisms in cancer prevention, may work synergistically. However, the knowledge with respect to the viewpoints above are still relatively lacking and require further research.
The aim of the present special issue is to provide the principles, overviews as well as ongoing research in this field. The current knowledge of cancer chemoprevention highlighted in this special issue may provide the useful information for those entering this field and encourage new ideas for future studies.
Submission Deadline31 May 2022