- Prof. Christos A. Papadimitriou, MD, PhD
- Oncology Unit, Second Department of Surgery, “Aretaieion” University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
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- Prof. Flora Zagouri, MD, PhD
- Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
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Special Issue Introduction
Breast cancer is the most common malignancy and the second leading cause of cancer-related mortality among women worldwide. Metastatic breast cancer is responsible for > 90% of tumor-related deaths, often due to the impairment of vital organ function. Metastatic relapse can occur months to decades after initial diagnosis and treatment. Although the incidence of distant relapses has been shown to decrease and survival times for patients with recurrent disease have improved, 20-30% of patients with early breast cancer still die from metastatic disease. This special issue focuses on the multistep process of metastatic recurrence, the phenomenon of tumor dormancy, factors that determine the preference of metastatic lesions to develop at specific anatomic sites, monitoring and evaluating both response to treatment and disease progression, as well as developments in the systemic therapeutic approach of the various breast cancer subtypes with particular emphasis on immunotherapy and molecularly targeted treatments (including CDK4/6 inhibitors), and molecular mechanisms mediating endocrine resistance in hormone receptor-positive breast cancers.
Professor Christos A. Papadimitriou, MD, PhD
Professor Flora Zagouri, MD, PhD
Submission Deadline31 Jul 2022