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Biomarker Discovery Autophagy and Cancer Breast Cancer Metastasis Brain Metastases Gastric Cancer Metastasis Lung Cancer Genetic Heterogeneity Colorectal Cancer Prostate Cancer Cancer Immunotherapy Circulating Tumor Cells Neuroendocrine Tumors

Volume 3(2017)

Cover Picture: NF-kB activation is an important cellular response to genotoxic stress. The signaling cascade transducing nuclear DNA damage signals through retrograde nuclear-to-cytoplasmic signaling to activate NF-kB. This signaling cascade involves a variety of posttranslational modifications, such as SUMOylation,  ubiquitylation and phosphorylation, of several key proteins including ATM. NEMO, TRAF6, and ELKS. The sequential modifications of NEMO guide its cytoplasmic/nuclear localization which bridges the nuclear DNA damage and cytoplasmic NF-kB activation. Activated NF-kB then translocates into the nucleus, and drive transactivation of anti-apoptotic genes, inflammatory cytokines, and oncogenic miRNAs, resulting in therapeutic resistance and aggressive metastasis in cancer cells.
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Editorial

Topic: Circulating Tumor Cells: Diagnostics and Clinical Applications

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Letter to Editor

Case Report

Review

Commentary

Short Communication

Topic: Cancer Immunotherapy

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