fig4

Figure 4. MiRNAs expression spectrum in MB cell lines, their corresponding CM and in CSF (a) Quantitative Venn diagram showing miRNAs commonly expressed in indicated cell lines and their corresponding CM. Differences linked to the expression level rather than detection threshold; (b) Venn diagram showing that 156 miRNAs enriched in CM of MB cell lines compared to their cell lysates and 57 miRNAs enriched in CM of the MR D283 and D341 but not in DAOY. Fold change > 2; (c) Venn diagram demonstrating miRNAs with high expression in CSF of MB patient compared to controls. TB0021_CTR1: CSF of leukemia with no brain tumor (patient control 1); TB0012_CTR2: leukemia with no brain tumor (patient control 2); TB0011_MB: CSF of MB patient. MB: Medulloblastoma; CSF: Cerebral spinal fluid; CM: Culture-medium; MiRNAs: MicroRNAs