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    Original Article| Open Access

    Tumor cell invasion from the marginal sinus into extranodal veins during early-stage lymph node metastasis can be a starting point for hematogenous metastasis

    Tetsuya Kodama, Shiro Mori, Masato Nose

    Aim: To investigate whether tumor cells in a lymph node (LN) can invade from the marginal sinus into extranodal veins via vessel branches that communicate with intranodal veins and whether this can be a starting point for hematogenous metastasis at the early stage of LN metastasis. Methods:... Read more

    This article belongs to the Special Issue Breast Cancer Metastasis J Cancer Metastasis Treat 2018;4:56. | doi:10.20517/2394-4722.2018.61
    Published on: 9 Nov 2018  | Viewed:285  | Downloaded:21
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    Review| Open Access

    Immunotherapy in colorectal cancer treatment: actual landscape and future perspectives

    Alessandro Bittoni, Valeria Sotte, Tania Meletani, Luca Cantini, Riccardo Giampieri, Rossana Berardi

    Colorectal cancer (CRC) represents the second most common cancer in Europe with marked differences in prognosis and response to treatments. In the past years research showed emerging interest in genomic and immunologic fields. The clinical heterogeneity, that occurs during the pathogenesis of... Read more

    This article belongs to the Special Issue Colorectal Cancer Progression and Treatment J Cancer Metastasis Treat 2018;4:55. | doi:10.20517/2394-4722.2018.37
    Published on: 26 Oct 2018  | Viewed:335  | Downloaded:12
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    Review| Open Access

    Circulating tumor cells and the metastatic process: the complexity of malignancy

    Tania Di Raimo, Elena De Santis, Luigi Coppola, Mario Rosario D’Andrea, Francesco Angelini

    Despite improvements achieved in terms of early detection and therapeutic approach, metastatic breast cancer remains one of the principal worldwide causes of death. In recent years, due to the heterogeneous response of each patient to chemotherapy, clinical research highlights the need of a... Read more

    This article belongs to the Special Issue Breast Cancer Metastasis J Cancer Metastasis Treat 2018;4:54. | doi:10.20517/2394-4722.2018.50
    Published on: 25 Oct 2018  | Viewed:608  | Downloaded:79
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    Original Article| Open Access

    Secondary malignancy estimation in patients after mastectomy and adjuvant therapy

    Oludare Folajimi Adeyemi, Okhuomaruyi David Osahon, Enosakhare Godwin Okungbowa

    Aim: Secondary malignancy estimation after radiotherapy of post mastectomy patients is becoming an important subject for comparative treatment planning. The data from modern treatment planning systems provide accurate three-dimensional dose distributions for each individual patients, thereby... Read more

    J Cancer Metastasis Treat 2018;4:53. | doi:10.20517/2394-4722.2018.12
    Published on: 8 Oct 2018  | Viewed:557  | Downloaded:25
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    Perspective| Open Access

    Pharmacogenetics and cancer management

    Harish Padh

    The science of one’s genetic background and its impact on disease susceptibility and drug response has come of age and firmly established its proper place in the clinic. Its impact is felt more in the treatment of cancer than any other disease area several reasons: critical time, narrow... Read more

    This article belongs to the Special Issue Cancer Pharmacogenomics J Cancer Metastasis Treat 2018;4:52. | doi:10.20517/2394-4722.2018.51
    Published on: 29 Sep 2018  | Viewed:439  | Downloaded:16
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    Original Article| Open Access

    Two sides to colon cancer: mice mimic human anatomical region disparity in colon cancer development and progression

    Jessica Felton, Kunrong Cheng, Aaron C. Shang, Shien Hu, Shannon M. Larabee, Cinthia B. Drachenberg, Jean-Pierre Raufman

    Aim: Strong evidence reveals important differences between cancers in the proximal vs. distal colon. Animal models of metastatic colon cancer are available but with varying degrees of reproducibility and several important limitations. We explored whether there were regional differences in the... Read more

    This article belongs to the Special Issue Colorectal Cancer Progression and Treatment J Cancer Metastasis Treat 2018;4:51. | doi:10.20517/2394-4722.2018.39
    Published on: 27 Sep 2018  | Viewed:520  | Downloaded:22
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    Case Report| Open Access

    Cryptic NUP214-ABL1 fusion with complex karyotype, episomes and intra-tumor genetic heterogeneity in a T-cell lymphoblastic lymphoma

    Moneeb A.K Othman, Beate Grygalewicz, Agnieszka Kołkowska-Leśniak, Joana B. Melo, Isabel M. Carreira, Thomas Liehr

    T-lymphoblastic lymphoma (T-LBL) is a rare and aggressive form of non-Hodgkin’s lymphoma and little is known about their molecular background. However, complex karyotypes were already related to this group of malignancy and associated with poor outcome. Here, we describe a 17-year-old female... Read more

    This article belongs to the Special Issue Intra-Tumour Genetic Heterogeneity J Cancer Metastasis Treat 2018;4:50. | doi:10.20517/2394-4722.2018.41
    Published on: 21 Sep 2018  | Viewed:714  | Downloaded:27
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    Review| Open Access

    NSAID celecoxib: a potent mitochondrial pro-oxidant cytotoxic agent sensitizing metastatic cancers and cancer stem cells to chemotherapy

    Stephen John Ralph, Sam Nozuhur, Rafael Moreno-Sánchez, Sara Rodríguez-Enríquez, Rhys Pritchard

    Intermittent hypoxia within tumor microenvironments causes pro-oxidative stress impairing oxidative phosphorylation (OxPhos) and increases mitochondrial production of reactive oxygen species (ROS). In primary tumors this provokes metabolic reprogramming of both tumor cells and cancer stem cells... Read more

    J Cancer Metastasis Treat 2018;4:49. | doi:10.20517/2394-4722.2018.42
    Published on: 20 Sep 2018  | Viewed:1145  | Downloaded:60
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    Editorial| Open Access

    Introduction to the special issue on reviews of gastric cancer metastasis and treatment

    Masayuki Watanabe This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment J Cancer Metastasis Treat 2018;4:48. | doi:10.20517/2394-4722.2018.60
    Published on: 17 Sep 2018  | Viewed:430  | Downloaded:25
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    Review| Open Access

    Unmasking tumor heterogeneity and clonal evolution by single-cell analysis

    Xiaoshan Shi, Papia Chakraborty, Amitabha Chaudhuri

    The intratumoral heterogeneity orchestrated by the tumor intrinsic and extrinsic mechanisms enable cancers to persist and spread notwithstanding the use of aggressive interventional therapies. The heterogeneity is revealed at multiple levels - at the level of individual tumor cells, in the... Read more

    This article belongs to the Special Issue Intra-Tumour Genetic Heterogeneity J Cancer Metastasis Treat 2018;4:47. | doi:10.20517/2394-4722.2018.32
    Published on: 31 Aug 2018  | Viewed:2193  | Downloaded:142
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