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    Review| Open Access

    Prostate cancer cells at a therapeutic gunpoint of the autophagy process

    Fabio Gabriele , Carolina Martinelli , Sergio Comincini

    In a normal prostate, the process of controling cell death is essential to maintain tissue homeostasis and its inhibition may lead to the development of cancer. Androgen receptor signaling plays pivotal roles in the prostate development and homeostasis as well as in the progression of prostate... Read more

    This article belongs to the Special Issue Autophagy and Cancer: current biology and drug development J Cancer Metastasis Treat 2018;4:17. | doi:10.20517/2394-4722.2018.06
    Published on: 19 Apr 2018  | Viewed:36  | Downloaded:6
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    Meta-Analysis| Open Access

    The potential prognostic and predictive roles of programmed cell death protein 1 expressed by tumor-infiltrating lymphocytes in solid tumors: a meta-analysis

    Dong-Yun Zhang , Rong-Zhi Liu , Jian-Wei Ku , Yu-Hong Ma , Ying-Jie Yi

    Aim: Several previous studies have evaluated the potential role of programmed cell death protein 1 (PD-1) expressed by tumor-infiltrating lymphocytes (TILs) in various solid tumors and performed its prognosis role in patients’ survival with inconsistent results. This study aims to further... Read more

    J Cancer Metastasis Treat 2018;4:16. | doi:10.20517/2394-4722.2018.01
    Published on: 12 Apr 2018  | Viewed:87  | Downloaded:26
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    Original Article| Open Access

    Nodal involvement and p16-staining in upper alveolar ridge and hard palate cancer

    Edgar Salas , Pedro Sanchez , Juan Postigo , Carlos A. Castaneda , Miluska Castillo , Valeria Villegas , Luis Cano , Sandro Casavilca , Luis A. Bernabe , Carolina Belmar , Maria R. Villa-Robles , Raul Mantilla , Henry Guerra

    Aim: Upper alveolar ridge and hard palate squamous cancer is an infrequent malignancy. We evaluated factors associated with neck involvement and with p16-staining. Methods: Head and neck squamous-cell carcinoma (SCC) patients who went to Head and Neck Department between 1997 and 2011 were... Read more

    J Cancer Metastasis Treat 2018;4:15. | doi:10.20517/2394-4722.2017.66
    Published on: 28 Mar 2018  | Viewed:329  | Downloaded:20
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    Review| Open Access

    The magnitude of benefit from adding taxanes to anthracyclines in the adjuvant settings of breast cancer: discussion of large trials and meta-analyses

    Osama H. Elzaafarany , Atlal Abusanad

    The taxanes family of chemotherapy, which includes paclitaxel and docetaxel, has been incorporated in the adjuvant breast cancer treatments since 1990s. Sequential and concurrent use of taxanes was investigated with anthracyclines in many adjuvant early breast cancer randomized clinical trials.... Read more

    J Cancer Metastasis Treat 2018;4:14. | doi:10.20517/2394-4722.2017.55
    Published on: 15 Mar 2018  | Viewed:432  | Downloaded:29
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    Commentary| Open Access

    Targeting adenosine receptor 2B in triple negative breast cancer

    Carola A. Neumann , Kevin Levine , Steffi Oesterreich J Cancer Metastasis Treat 2018;4:13. | doi:10.20517/2394-4722.2017.60
    Published on: 15 Mar 2018  | Viewed:508  | Downloaded:44
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    Review| Open Access

    Pharmacogenomics in colorectal cancer: current role in clinical practice and future perspectives

    Francesca Battaglin , Alberto Puccini , Madiha Naseem , Marta Schirripa , Martin D. Berger , Ryuma Tokunaga , Michelle McSkane , Taline Khoukaz , Shivani Soni , Wu Zhang , Heinz-Josef Lenz

    The treatment scenario of colorectal cancer (CRC) has been evolving in recent years with the introduction of novel targeted agents and new therapeutic strategies for the metastatic disease. An extensive effort has been directed to the identification of predictive biomarkers to aid patients... Read more

    This article belongs to the Special Issue Cancer Pharmacogenomics J Cancer Metastasis Treat 2018;4:12. | doi:10.20517/2394-4722.2018.04
    Published on: 7 Mar 2018  | Viewed:805  | Downloaded:86
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    Review| Open Access

    Current challenges and opportunities in treating hypoxic prostate tumors

    Declan J. McKenna , Rachel Errington , Klaus Pors

    Hypoxia is a well-established characteristic of prostate tumors and is now recognised as a major contributory factor to both tumor progression and increased resistance to therapy. One strategy to target hypoxic tumor cells is the development of hypoxia-activated prodrugs (HAPs), which are... Read more

    This article belongs to the Special Issue How does the prostate cancer microenvironment affect the metastatic process and/or treatment outcome? J Cancer Metastasis Treat 2018;4:11. | doi:10.20517/2394-4722.2017.54
    Published on: 1 Mar 2018  | Viewed:1346  | Downloaded:134
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    Review| Open Access

    Microenvironment in the pathogenesis of gastric cancer metastasis

    Hiroshi Sawayama , Takatsugu Ishimoto , Hideo Baba

    Tumor tissues contain cancer cells, other cellular and non-cellular components. Tumor microenvironments consist of cancer cells and various types of stromal cells, cancer associated fibroblasts, bone marrow-derived cells, endothelial cells, and hematopoietic cells, mainly tumor-associated... Read more

    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment J Cancer Metastasis Treat 2018;4:10. | doi:10.20517/2394-4722.2017.79
    Published on: 28 Feb 2018  | Viewed:611  | Downloaded:68
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    Review| Open Access

    Therapeutic targets against gastric cancer stem cells interacting with tumor microenvironment

    Tomoyuki Uchihara , Takatsugu Ishimoto , Atsuko Yonemura , Hideo Baba

    Gastric cancer (GC) is a major cause of cancer-related deaths worldwide. The existence of cancer stem cells (CSCs) is known to be the main reason for resistance to anticancer agents as well as for the development of distant metastases. Although CSCs themselves harbor self-renewal and... Read more

    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment J Cancer Metastasis Treat 2018;4:9. | doi:10.20517/2394-4722.2017.81
    Published on: 26 Feb 2018  | Viewed:651  | Downloaded:77
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    Review| Open Access

    Significance of peritoneal lavage cytology based on genetic signatures in gastric cancer

    Tasuku Matsuoka , Masakazu Yashiro

    Peritoneal metastasis is the most common pattern of recurrence and the most frequent cause of death after surgery in patients with gastric cancer. Peritoneal free cancer cells disseminated from the primary lesion site have been considered the main cause of peritoneal metastasis. Peritoneal lavage... Read more

    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment J Cancer Metastasis Treat 2018;4:6. | doi:10.20517/2394-4722.2017.85
    Published on: 9 Feb 2018  | Viewed:672  | Downloaded:54
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