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  • 18 Sep
    2016
    Review

    The features of peritoneal metastases from gastric cancer

    Gianni Mura , Beatrice Verdelli
    Peritoneal Carcinomatosis (PC) from metastasization of Gastric Cancer (GC), either present at first diagnosis of GC or as recurrence, is considered a fatal disease with no hope of definitive cure. Although newer agents like S1 and docetaxel have shown some promise, the median overall survival with the current first line chemotherapy is only 8 to 14 months, and is not greatly improved by adding targeted therapy. A multi-modal approach with cytoreductive surgery (CRS) associated with hyperthermic intraperitoneal chemotherapy (HIPEC) has been developed along the last two decades in order to...
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  • 18 Sep
    2016
    Case Report

    Pediatric gliomatosis cerebri presenting with intratumoral hemorrhage leading to poor outcome

    Hiromasa Adachi , Masashi Kitagawa , Toshinari Kawasaki , Takafumi Wataya
    Gliomatosis cerebri (GC) is an uncommon disease, defined as diffuse infiltration of neoplastic glial cells involving at least three cerebral lobes. GCs in young population are rare. We described a case of 14-year-old woman with GC who did not receive any recommended treatment, because the patient’s family refused. The patient had a rapid deterioration in 5 months after first symptoms due to intratumoral bleeding. This is the first case report of intratumoral bleeding after diagnosis of GC is made, resulting in poor outcome. GC may acquire possibility of intratumoral hemorrhage through its...
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  • 18 Sep
    2016
    Review

    Function of cancer cell-derived extracellular matrix in tumor progression

    Gao-Feng Xiong , Ren Xu
    Extracellular matrix (ECM) is an essential component of the tumor microenvironment. Cancer development and progression are associated with increased ECM deposition and crosslink. The chemical and physical signals elicited from ECM are necessary for cancer cell proliferation and invasion. It is well recognized that stromal cells are a major source of ECM proteins. However, recent studies showed that cancer cells are also an active and important component in ECM remodeling. Cancer cells deposit a significant amount of collagen, fibronectin, and tenascin C (TNC). Recent studies demonstrate...
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  • 31 Aug
    2016
    Topic: Neuroendocrine Tumors

    Circulating neuroendocrine tumors biomarkers. Why? When? How? Suggestions for clinical practice from guidelines and consensus

    Paola Razzore , Giorgio Arnaldi
    Neuroendocrine neoplasms (NETs) are rare tumors that are increasing in incidence. NETs are characterized by heterogeneous biological behaviour, clinical presentation and course. A sensitive and specific diagnostic and prognostic circulating biomarker useful for all sites, grading and staging of neuroendocrine tumors is still an unmet need. The aim of this article was to review current neuroendocrine and oncologic scientific society guidelines and position statements, and propose recommendations for the most frequent clinical practice queries on circulating neuroendocrine tumors biomarkers....
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  • 31 Aug
    2016
    Topic: Neuroendocrine Tumors

    Pancreatic neuroendocrine tumor with hypoglycemia and elevated insulin-like growth factor II: a case report

    Roberta Modica , Antonella Di Sarno , Annamaria Colao , Antongiulio Faggiano
    Pancreatic neuroendocrine tumors (pNETs) can be associated with different clinical syndromes. Insulinoma is the most common functioning pNET characterized by hypoglycemia and hyperinsulinemia. The authors report a case of a man presenting with hypoglycemia and biochemical features of insulinoma. A pancreatic lesion was found and growth hormone (GH) deficiency was also diagnosed associated with an empty sella present on the pituitary magnetic resonance imaging. The disappearance of hypoglycemia and normalization of GH secretion after surgical resection of the pancreatic lesion, revealed a...
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  • 31 Aug
    2016
    Topic: Neuroendocrine Tumors

    Orbital lesions, an exceedingly rare site of neuroendocrine tumor metastasis

    Sara Pusceddu , Massimo Milione , Silvia Ortolani , Alessio Pellegrinelli , Marco Brugia , Filippo de Braud , Lorenzo Antonuzzo
    Neuroendocrine tumors are rare neoplasms arising primarily in the gastrointestinal tract and lung. The liver is the most common site of metastases, but these tumors can rarely metastasize to atypical sites. Surgery is the only curative approach while the optimal medical treatment is debated. From this perspective, a multidisciplinary approach for each single case becomes very important. In this report we describe the case of a male affected by a single intraorbital metastasis from a midgut well differentiated neuroendocrine tumor. The patient refused surgical removal and therefore he was at...
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