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    Original Article| Open Access

    New insights into the role of intra-tumor genetic heterogeneity in carcinogenesis: identification of complex single gene variance within tumors

    Bruce Gottlieb , Farbod Babrzadeh , Kathleen Klein Oros , Carlos Alvarado , Chunlin Wang , Baback Gharizadeh , Mark Basik , Celia M.T. Greenwood , Lenore K. Beitel , Mark Trifiro

    Aim: Present cancer hypotheses are almost all based on the concept that accumulation of specific driver gene mutations cause carcinogenesis. The discovery of intra-tumor genetic heterogeneity (ITGH), has resulted in this hypothesis being modified by assuming that most of these ITGH mutations are... Read more

    This article belongs to the Special Issue Intra-Tumour Genetic Heterogeneity J Cancer Metastasis Treat 2018;4:37. | doi:10.20517/2394-4722.2018.26
    Published on: 19 Jul 2018  | Viewed:0  | Downloaded:0
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    Review| Open Access

    Circulating microRNAs as a liquid biopsy: a next-generation clinical biomarker for diagnosis of gastric cancer

    Shuhei Komatsu , Jun Kiuchi , Taisuke Imamura , Daisuke Ichikawa , Eigo Otsuji

    Accumulating evidence has suggested the potential clinical utility of novel body fluid biomarkers, or “liquid biopsy”, using circulating tumor cells and cell-free nucleic acids from cancer patients. Noninvasive and reproducible, liquid biopsy could provide the basis for individualized therapeutic... Read more

    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment J Cancer Metastasis Treat 2018;4:36. | doi:10.20517/2394-4722.2017.58
    Published on: 18 Jul 2018  | Viewed:0  | Downloaded:0
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    Review| Open Access

    Current trends in gastric cancer treatment in Europe

    Satoshi Kamiya , Ioannis Rouvelas , Mats Lindblad , Magnus Nilsson

    Gastric cancer is one of the major causes of cancer-related deaths, despite the gradual decrease of its incidence in the West. Minimally invasive procedures, such as endoscopic resection and laparoscopic gastrectomy, have been successfully introduced in European high-volume centres, in the... Read more

    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment J Cancer Metastasis Treat 2018;4:35. | doi:10.20517/2394-4722.2017.76
    Published on: 17 Jul 2018  | Viewed:172  | Downloaded:8
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    Systematic Review| Open Access

    Surgical treatment of stage IV gastric cancer: is it worthwhile?

    Ilaria Pergolini , Paolo Ciano , Gianluca Guercioni , Marco Catarci

    Aim: To analyze clinical features and survival outcomes of patients with surgically-treated stage IV gastric cancer, in order to evaluate the suitability of surgery in these patients. Methods: We performed a systematic literature search using PubMed, MEDLINE, and Embase on October 9th, 2017.... Read more

    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment J Cancer Metastasis Treat 2018;4:33. | doi:10.20517/2394-4722.2017.84
    Published on: 17 Jul 2018  | Viewed:228  | Downloaded:14
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    Case Report| Open Access

    Necrotizing fasciitis as a complication of taxanes: a case report

    Nasser Mohammed Amer , Rabia Niaz

    Necrotizing fasciitis is a rare complication of chemotherapy, however, few reports were published as a specific complication of taxanes. We are reporting this rare complication of a lady who was treated with taxanes as an adjuvant therapy for her breast cancer who was referred to us from the... Read more

    J Cancer Metastasis Treat 2018;4:34. | doi:10.20517/2394-4722.2018.09
    Published on: 17 Jul 2018  | Viewed:100  | Downloaded:4
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    Review| Open Access

    Circulating tumor cells in gastric cancer

    Kenichi Nakamura , Masaaki Iwatsuki , Junji Kurashige , Takatsugu Ishimoto , Yoshifumi Baba , Yuji Miyamoto , Naoya Yoshida , Masayuki Watanabe , Hideo Baba

    Circulating tumor cells (CTCs) have received a lot of attention as a novel biomarker for cancer research in past decades. CTCs infiltrate the bloodstream derived from the primary tumor, and are significantly involved in cancer metastasis and recurrence. Although clinical applications have been... Read more

    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment J Cancer Metastasis Treat 2018;4:32. | doi:10.20517/2394-4722.2017.78
    Published on: 5 Jul 2018  | Viewed:168  | Downloaded:105
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    Review| Open Access

    Update on targeted therapy and immune therapy for gastric cancer, 2018

    Yuki Kiyozumi , Masaaki Iwatsuki , Kohei Yamashita , Yuki Koga , Naoya Yoshida , Hideo Baba

    Gastric cancer (GC) remains one of the most common cancers and serious health problems worldwide. For unresectable or metastatic advanced gastric cancer, chemotherapy treatment is first selected. Although chemotherapy has improved survival in patients with advanced gastric cancer (AGC), the... Read more

    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment J Cancer Metastasis Treat 2018;4:31. | doi:10.20517/2394-4722.2017.77
    Published on: 28 Jun 2018  | Viewed:466  | Downloaded:129
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    Review| Open Access

    Pancreatic cancer: treatment approaches and trends

    Nabyla Paixão Pereira , José Raimundo Corrêa

    Pancreatic cancer is one of the most challenging diseases due to its often late diagnose which results in limited therapeutic options and poor prognosis. To date, the only curative treatment is complete tumor removal surgery but only a few patients are eligible to do it. The median survival... Read more

    J Cancer Metastasis Treat 2018;4:30. | doi:10.20517/2394-4722.2018.13
    Published on: 25 Jun 2018  | Viewed:274  | Downloaded:33
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    Editorial| Open Access

    Bioconjugate structures vs. composite nanoparticulate carriers: the battle for the future of smart, effective and safe cancer management

    Mohamed Ismail Nounou J Cancer Metastasis Treat 2018;4:29. | doi:10.20517/2394-4722.2018.18
    Published on: 21 Jun 2018  | Viewed:221  | Downloaded:28
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    Review| Open Access

    Immunotherapy in the treatment of colorectal cancer: a new kid on the block

    Andrea Spallanzani , Fabio Gelsomino , Francesco Caputo , Chiara Santini , Kalliopi Andrikou , Giulia Orsi , Margherita Rimini , Stefania Pipitone , Laura Riggi , Camilla Bardasi , Massimiliano Salati , Stefano Cascinu

    In the last few years, the success of anti-PD1 and anti-PDL1 drugs in solid cancers treatment and the advances in molecular biology have provided new potential treatment strategies for patients with metastatic colorectal cancer. Unfortunately, only patients with mismatch repair deficiency seem to... Read more

    This article belongs to the Special Issue Colorectal Cancer Progression and Treatment J Cancer Metastasis Treat 2018;4:28. | doi:10.20517/2394-4722.2018.31
    Published on: 19 Jun 2018  | Viewed:722  | Downloaded:98
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