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    Original Article| Open Access

    Health-related quality of life and its correlates among rectal cancer survivors, Northwest of Iran

    Nayyereh Aminisani , Mehdi Fatemi , Parvin Sarbakhsh , Alireza Nikanfar , Amirtaher Eftekharsadat , Esmat Jafari

    Aim: The objective of this study was to examine the health-related quality of life (HRQOL), and its correlates among rectal cancer survivors in northwest of Iran. Methods: This cross-sectional study was conducted in northwest of Iran. Rectal cancer survivors were selected from teaching hospitals.... Read more

    J Cancer Metastasis Treat 2017;3:209-16. | doi:10.20517/2394-4722.2017.47
    Published on: 29 Sep 2017  | Viewed:172  | Downloaded:14
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    Review| Open Access

    Using circulating tumor cells to advance precision medicine in prostate cancer

    Giuseppe Galletti , Daniel Worroll , David M. Nanus , Paraskevi Giannakakou

    The field of circulating tumor cell (CTC) enrichment has seen many emerging technologies in recent years, which have resulted in the identification and monitoring of clinically relevant, CTC-based biomarkers that can be analyzed routinely without invasive procedures. Several molecular platforms... Read more

    J Cancer Metastasis Treat 2017;3:190-205. | doi:10.20517/2394-4722.2017.45
    Published on: 27 Sep 2017  | Viewed:321  | Downloaded:19
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    Commentary| Open Access

    Adenosine A2B receptor: novel anti-cancer therapeutic implications

    Silvia Paola Corona , Navid Sobhani , Daniele Generali J Cancer Metastasis Treat 2017;3:206-8. | doi:10.20517/2394-4722.2017.50
    Published on: 27 Sep 2017  | Viewed:322  | Downloaded:13
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    Original Article| Open Access

    Malignant field expression signatures in biopsy samples at diagnosis predict the likelihood of lethal disease in patients with localized prostate cancer

    Gennadi V. Glinsky

    Aim: Overtreatment of early-stage low-risk prostate cancer patients represents a significant problem in disease management and has significant socio-economic implications. Changes in prostate cancer screening and treatment practices in the United States have been associated with the recent... Read more

    J Cancer Metastasis Treat 2017;3:177-89. | doi:10.20517/2394-4722.2017.43
    Published on: 21 Sep 2017  | Viewed:272  | Downloaded:11
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    Original Article| Open Access

    The synergy of Helicobacter pylori and lipid metabolic disorders in induction of Th17-related cytokines in human gastric cancer

    Jie Liu , Han Wang , Gang Chen , Mo Yang , Zhi-Xian Wu , Russell Erick Ericksen , Alice Sze Tsai Wong , Weiping Han , Jin-Zhang Zeng

    Aim: To study the impact of Helicobacter pylori (H. pylori) and lipid metabolic disorder on the expression of Th17-related cytokines in gastric cancer (GC). Methods: GC specimens were randomly collected from 42 patients, of whom 15 had H. pylori infection and 27 were without. Tumor RNA was... Read more

    J Cancer Metastasis Treat 2017;3:169-76. | doi:10.20517/2394-4722.2017.46
    Published on: 29 Aug 2017  | Viewed:530  | Downloaded:52
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    Original Article| Open Access

    Papaya black seeds have beneficial anticancer effects on PC-3 prostate cancer cells

    Khalid S. Alotaibi , Haiwen Li , Reza Rafi , Rafat A. Siddiqui

    Aim: The study investigated the effect of papaya seeds on prostate cancer (PC) using PC-3 cell line because papaya seeds have effects on the male reproductive system notably decreasing sperm concentration, motility, and viability, leading to azoospermia after short-to-long-term treatment.... Read more

    J Cancer Metastasis Treat 2017;3:161-8. | doi:10.20517/2394-4722.2017.33
    Published on: 28 Aug 2017  | Viewed:804  | Downloaded:66
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    Original Article| Open Access

    TGF-β stimulation of EMT programs elicits non-genomic ER-α activity and anti-estrogen resistance in breast cancer cells

    Maozhen Tian , William P. Schiemann

    Aim: Estrogen receptor-α (ER-α) activation drives the progression of luminal breast cancers. Signaling by transforming growth factor-β (TGF-β) typically opposes the actions of ER-α; it also induces epithelial-mesenchymal transition (EMT) programs that promote breast cancer dissemination, stemness... Read more

    J Cancer Metastasis Treat 2017;3:150-60. | doi:10.20517/2394-4722.2017.38
    Published on: 21 Aug 2017  | Viewed:987  | Downloaded:84
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    Case Report| Open Access

    Uterine large cell neuroendocrine carcinoma with unusual colonic metastasis

    Antonio Ieni , Giuseppe Angelico , Rosalba De Sarro , Francesco Fleres , Antonio Macrì , Giovanni Tuccari

    A 78-year-old female patient arrived at our practice complaining of progressive abdominal increase and presenting a clinical picture of intestinal obstruction. At physical examination, the abdomen appeared distended, moderately painful with the presence of a mass of hard consistency. Abdominal... Read more

    J Cancer Metastasis Treat 2017;3:144-9. | doi:10.20517/2394-4722.2017.15
    Published on: 16 Aug 2017  | Viewed:503  | Downloaded:43
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    Case Report| Open Access

    Large chest wall fibromatosis with challenging treatment plan

    Rashi Agrawal , Prekshi Choudhary , Arun Kumar Goel , Vaishali Zamre , Sandeep Agarwal , Dinesh Singh

    The primary mode of treatment for desmoid tumors is surgical excision. However, high recurrence rates (39-79%) have been reported when surgery is used alone. The role of adjuvant radiotherapy after surgical resection of primary disease is controversial and should be based on a balanced discussion... Read more

    J Cancer Metastasis Treat 2017;3:139-43. | doi:10.20517/2394-4722.2017.02
    Published on: 21 Jul 2017  | Viewed:610  | Downloaded:76
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    Review| Open Access

    Role of adenosine in tumor progression: focus on A2B receptor as potential therapeutic target

    Claudia Sorrentino , Silvana Morello

    Adenosine receptors are a family of G-coupled receptors which mediate the anti-inflammatory and immune-suppressive effects of adenosine in a damaged tissue. A large number of evidence indicate that the accumulation of adenosine under hypoxic conditions favors tumor progression, helping cancer... Read more

    J Cancer Metastasis Treat 2017;3:127-38. | doi:10.20517/2394-4722.2017.29
    Published on: 17 Jul 2017  | Viewed:1451  | Downloaded:166
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