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From: Tumor heterogeneity and therapy resistance - implications for future treatments of prostate cancer
Figure 1. Heterogeneity in prostate cancer. When considering the task of improving current prostate cancer treatments or developing novel therapies, multiple types of heterogeneity have to be taken into account. These include patient tumor heterogeneity, multi-focal disease, intra-tumor cellular heterogeneity, genomic heterogeneity including mutations and gene fusions and finally epigenetic heterogeneity with inherent differences between cell populations but also the possibility of therapy-induced epigenetic changes
