fig6
From: Tumor heterogeneity and therapy resistance - implications for future treatments of prostate cancer
Figure 6. Consequences of treatment; paths to resistance or death. Inducing cell death in cancer cells is not a single pathway and initial treatments may push cells to many different outcomes. To overcome cell thresholds and safeguards and push cells towards cell death, other stimuli may be required. This could involve sensitisers to make the initial treatment more effective or it could include inhibitors to prevent activation of cell survival mechanisms. Heterogeneity of response dictates that combination treatments are likely to be more effective
