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Figure 2. GES-based identification of lethal disease in Gleason 6 and 7 prostate cancer patients. Kaplan-Meier survival analysis of the classification performance of the 98 genes GES in 200 Gleason 6 and 7 prostate cancer patients (A), 83 Gleason 6 patients (B), and 117 Gleason 7 patients (C). Classification threshold 98 genes GES score of 270.43 units was chosen using the training set of 141 prostate cancer patients and consistently applied in all subsequent validation screens using the Kaplan-Meier survival analysis to stratify the patients into lethal disease sub-groups (score ≥ 270.43) and moderate/aggressive disease sub-group (score < 270.43). Percent values indicate the proportion of patients in the lethal disease sub-group. P values indicate the significance of the differences in the numbers of death events and surviving patients between the groups which was determined using two-sided Fisher's exact test. GES: gene expression signatures