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Figure 5. GES-based identification of lethal disease in Gleason 6 and 7 prostate cancer patients with distinct numbers of cancer cells in biopsy samples. Kaplan-Meier survival analysis of the classification performance of the 98 genes GES in 52 prostate cancer patients having 2% cancer cells in biopsy samples (A, top), 76 patients having 5% or less cancer cells in biopsy samples (A, bottom), 109 patients having 10% or less cancer cells in biopsy samples (B, top), 140 patients having 20% or less cancer cells in biopsy samples (B, bottom; and C, top), 167 patients having 40% or less cancer cells in biopsy samples (C, bottom). Classification threshold 98 genes GES score of 270.43 units was chosen using the training set of 141 prostate cancer patients and consistently applied in all subsequent validation screens using the Kaplan-Meier survival analysis to stratify the patients into lethal disease sub-groups (score ≥ 270.43) and moderate/aggressive disease sub-group (score < 270.43). Percent values indicate the proportion of patients in the lethal disease sub-group. P values indicate the significance of the differences in the numbers of death events and surviving patients between the groups which was determined using two-sided Fisher's exact test. GES: gene expression signatures