fig1

Figure 1. lncRNAs derive from a number of genetic loci and associate with specific lncRNA function. (A) pa-lncRNAs originate from a bi-directional promoter from the sense strand of gene foci. These lncRNAs tend to operate in cis and regulate the neighboring protein coding gene; (B) ea-lncRNAs are similar to pa-lncRNAs yet are transcribed from enhancer regions within the genome; (C) NAT-lncRNAs are transcribed from the antisense strand and contain fully or partially complementary sequences to sense-strand transcripts, depending upon the surrounding genetic elements that regulate transcription of NATs; (D) gb-lncRNAs are transcribed in sense orientation, typically are one exon in length, and could share exons from protein coding transcripts; (E) lincRNAs are transcribed from genetic loci in either sense or antisense fashion and span regions considered transcriptionally active, coding or otherwise. Portions of this figure were adapted from Martens-Uzunova et al.^[229], with permission