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Figure 1. Application of whole exome sequencing (WES) and single-cell sequencing (sc-sequencing) to cancer research. A: Overview of patient cases to which WES and sc-sequencing were applied to characterize different types of human cancers to understand ITH and tumor microenvironment. The various types of cancers include liver cancer, lung cancer, renal cell cancer, blood cancer, brain cancer, breast cancer, pancreatic cancer, colorectal cancer and ovarian cancer compiled from public databases; B: the number of publications reporting applications of either whole exome or single-cell sequencing to cancer patients within the recent ten years. The key words “exome/single-cell sequencing” and “cancer patients” were used for searching articles from NCBI