Topic: Intra-Tumour Genetic Heterogeneity

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A special issue of Journal of Cancer Metastasis and Treatment  (Print ISSN:2394-4722; Online ISSN:2454-2857).

Deadline for manuscript submissions: 31 Jul 2018

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Guest Editor(s)

  • Dr. Luciano G. Martelotto, PhD
    University of Melbourne, Center for Cancer Research, Melbourne, Victoria, Australia.

    Website | E-mail

  • Prof. Yi-Hong Zhou, PhD
    University of California, Irvine, Irvine, California, USA.

    Website | E-mail

Special Issue Introduction:


Tumour genetic heterogeneity has been documented in human cancers, and there is burgeoning evidence to demonstrate that a large proportion of cancers, at diagnosis, are composed of mosaics of genetically and phenotypically distinct tumor cell populations or “sub-clones”. Recent investigations have illustrated the likely biological and clinical impact of intra-tumour heterogeneity on cancer progression, metastasis, and therapeutic response. The characterization of tumour heterogeneity and sub-clonality is therefore important for furthering our understanding about cancer and for the development of improved and more precise therapeutics.
--------from Dr. Luciano G. Martelotto

Chromosome instability (CIN) and intra-tumoral heterogeneity (TH) are two hallmarks of cancer. Recent investigations have demonstrated the role of CIN, i.e. mis-segregation (MS) of a tumor-specific chromosome and mis-distribution of double minute chromosomes with oncogene amplifications, in controlling the phenotypic transition of cancer cells. This makes TH an inherited feature of both de novo (primary) and metastatic or recurrent tumors. CIN can readily and rapidly give rise to tumor cells with diverse genotypes, which leads to dramatic changes in transcriptional profiles, and thus affect the behavior and survivability of the progeny cells. Hence, CIN plays a critical role in cancer progression and resistance to conventional therapy. Paradoxically, on occasion, CIN interferes with cancer evolution by producing a large number of cells lacking oncogenic function and viability. In such cases, selection would be directed toward suppressing CIN in maintaining the functionally diverse tumor cell subpopulations. This leads to the ability to adjust the MS rate in proliferating tumor cells in accordance with extracellular cues in their microenvironment. Identifying inhibitor(s) of CIN and thereby disrupting the mechanisms maintaining the TH equilibrium needed for optimal tumor growth, would be an entirely new and exciting approach towards cancer treatment. This could lead to the development of powerful therapeutants that could not only treat existing cancer, but potentially prevent tumor recurrence after therapy.
--------from Prof. Yi-Hong Zhou

Keywords:

Intra-tumour genetic heterogeneity, single cell sequencing, clonality, bioinformatics, chromosome instability, intra-tumoral heterogeneity, inhibitor of CIN on chromosome mis-segregation/double minute mis-distribution, genetic, metabolic, and tumor-forming functional heterogeneities of tumor cell subpopulations

Submission Information:

Articles of special issue are free of charge for article processing.
For Author Instructions, please refer to http://jcmtjournal.com/pages/view/author_instructions
For Online Submission, please login at https://mc03.manuscriptcentral.com/jcmt
Submission Deadline: 31 Jul 2018
Contacts: Carrie Wang, Managing Editor, editor001@jcmtjournal.com

Published Articles Download All Articles
  • Centrosome aberrations and chromosome instability contribute to tumorigenesis and intra-tumor heterogeneity

    Shirley Jusino , Fabiola M. Fernández-Padín , Harold I. Saavedra
    Centrosomes serve as the major microtubule organizing centers in cells and thereby contribute to cell shape, polarity, and motility. Also, centrosomes ensure equal chromosome segregation during mitosis. Centrosome aberrations arise when the centrosome cycle is deregulated, or as a result of cytokinesis failure. A long-standing postulate is that centrosome aberrations are involved in the initiation and progression of cancer. However, this notion has been a subject of controversy because until recently the relationship has been correlative. Recently, it was shown that numerical or structural... Read more
    This article belongs to the Special Issue Intra-Tumour Genetic Heterogeneity
    J Cancer Metastasis Treat 2018;4:43. | doi:10.20517/2394-4722.2018.24
    Published on: 7 Aug 2018  | Viewed:117  | Downloaded:21
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  • Genomic heterogeneity meets cellular energetics: crosstalk between the mitochondria and the cell cycle

    Erica L. Herrera , Seham Z. Azzam , Madison C. Berger , Laura A. Diaz-Martinez
    Changes in cellular energetics and genomic instability are two characteristics of cancers that have been studied independently. Evidence of cross-talk between mitochondria function and nuclear function has started to emerge, suggesting that these pathways can influence one another. Here we review recent evidence that links the mitochondria and the cell cycle. This evidence indicates bidirectional cross-talk where mitochondria function can regulate the cell cycle and induce genomic instability, and conversely, the cell cycle machinery regulates mitochondria function. Implications for this... Read more
    This article belongs to the Special Issue Intra-Tumour Genetic Heterogeneity
    J Cancer Metastasis Treat 2018;4:42. | doi:10.20517/2394-4722.2018.35
    Published on: 6 Aug 2018  | Viewed:158  | Downloaded:24
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  • Extracellular control of chromosomal instability and maintenance of intra-tumoral heterogeneity

    Yi-Hong Zhou , Kambiz Afrasiabi , Mark E. Linskey
    Aim: Current cancer treatments are challenged by the plasticity of cancer cells, largely influenced by chromosomal instability (CIN) leading to variations in karyotype known as tumor-specific aneuploidy, which in turn, leads to intra-tumor cellular heterogeneity (TH). Cells with certain chromosomal defects often survive treatment and the growth-associated states of TH persist in recurrent tumors. Modulation of the CIN rate seems to reside within the tumor itself. In an attempt to develop a therapy targeting cancer plasticity, we studied the possible extracellular control of CIN rate in... Read more
    This article belongs to the Special Issue Intra-Tumour Genetic Heterogeneity
    J Cancer Metastasis Treat 2018;4:41. | doi:10.20517/2394-4722.2018.16
    Published on: 2 Aug 2018  | Viewed:175  | Downloaded:30
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  • New insights into the role of intra-tumor genetic heterogeneity in carcinogenesis: identification of complex single gene variance within tumors

    Bruce Gottlieb , Farbod Babrzadeh , Kathleen Klein Oros , Carlos Alvarado , Chunlin Wang , Baback Gharizadeh , Mark Basik , Celia M.T. Greenwood , Lenore K. Beitel , Mark Trifiro
    Aim: Present cancer hypotheses are almost all based on the concept that accumulation of specific driver gene mutations cause carcinogenesis. The discovery of intra-tumor genetic heterogeneity (ITGH), has resulted in this hypothesis being modified by assuming that most of these ITGH mutations are in passenger genes. In addition, accumulating ITGH data on driver gene mutations have revealed considerable genotype/phenotype disconnects. This study proposes to investigate this disconnect by examining the nature and degree of ITGH in breast tumors. Methods: ITGH was examined in tumors using next... Read more
    This article belongs to the Special Issue Intra-Tumour Genetic Heterogeneity
    J Cancer Metastasis Treat 2018;4:37. | doi:10.20517/2394-4722.2018.26
    Published on: 19 Jul 2018  | Viewed:303  | Downloaded:40
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Journal of Cancer Metastasis and Treatment ISSN 2454-2857 (Online), ISSN 2394-4722 (Print)
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