Special Issue on “Intra-Tumour Genetic Heterogeneity”
|Luciano G. Martelotto|
|Monash University, Monash Health, Clayton, Victoria, Australia.|
|Research Field: Cancer genomics, single cell sequening|
|Email: Luciano.Martelotto@monash.edu (also, firstname.lastname@example.org)|
|University of California, Irvine, Irvine, California, USA.|
|Research Field: Brain tumor biology, cancer evolution, and cancer therapy|
Introduction:Tumour genetic heterogeneity has been documented in human cancers, and there is burgeoning evidence to demonstrate that a large proportion of cancers, at diagnosis, are composed of mosaics of genetically and phenotypically distinct tumor cell populations or "sub-clones". Recent investigations have illustrated the likely biological and clinical impact of intra-tumour heterogeneity on cancer progression, metastasis, and therapeutic response. The characterisation of tumour heterogeneity and sub-clonality is therefore important for furthering our understanding about cancer and for the development of improved and more precise therapeutics.
Keywords:Intra-tumour genetic heterogeneity, single cell sequencing, clonality, bioinformatics, chromosome instability, intra-tumoral heterogeneity, inhibitor of CIN on chromosome mis-segregation/double minute mis-distribution, genetic, metabolic, and tumor-forming functional heterogeneities of tumor cell subpopulations.
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