Articles
  • Original Article|Open Access

    Malignant field expression signatures in biopsy samples at diagnosis predict the likelihood of lethal disease in patients with localized prostate cancer

    Gennadi V. Glinsky
    Aim: Overtreatment of early-stage low-risk prostate cancer patients represents a significant problem in disease management and has significant socio-economic implications. Changes in prostate cancer screening and treatment practices in the United States have been associated with the recent... Read more
    J Cancer Metastasis Treat 2017;3:177-89. | doi:10.20517/2394-4722.2017.43
    Published on: 21 Sep 2017  | Viewed:41  | Downloaded:2
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  • Original Article|Open Access

    The synergy of Helicobacter pylori and lipid metabolic disorders in induction of Th17-related cytokines in human gastric cancer

    Jie Liu , Han Wang , Gang Chen , Mo Yang , Zhi-Xian Wu , Russell Erick Ericksen , Alice Sze Tsai Wong , Weiping Han , Jin-Zhang Zeng
    Aim: To study the impact of Helicobacter pylori (H. pylori) and lipid metabolic disorder on the expression of Th17-related cytokines in gastric cancer (GC). Methods: GC specimens were randomly collected from 42 patients, of whom 15 had H. pylori infection and 27 were without. Tumor RNA was... Read more
    J Cancer Metastasis Treat 2017;3:169-76. | doi:10.20517/2394-4722.2017.46
    Published on: 29 Aug 2017  | Viewed:412  | Downloaded:41
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  • Original Article|Open Access

    Papaya black seeds have beneficial anticancer effects on PC-3 prostate cancer cells

    Khalid S. Alotaibi , Haiwen Li , Reza Rafi , Rafat A. Siddiqui
    Aim: The study investigated the effect of papaya seeds on prostate cancer (PC) using PC-3 cell line because papaya seeds have effects on the male reproductive system notably decreasing sperm concentration, motility, and viability, leading to azoospermia after short-to-long-term treatment.... Read more
    J Cancer Metastasis Treat 2017;3:161-8. | doi:10.20517/2394-4722.2017.33
    Published on: 28 Aug 2017  | Viewed:566  | Downloaded:50
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  • Original Article|Open Access

    TGF-β stimulation of EMT programs elicits non-genomic ER-α activity and anti-estrogen resistance in breast cancer cells

    Maozhen Tian , William P. Schiemann
    Aim: Estrogen receptor-α (ER-α) activation drives the progression of luminal breast cancers. Signaling by transforming growth factor-β (TGF-β) typically opposes the actions of ER-α; it also induces epithelial-mesenchymal transition (EMT) programs that promote breast cancer dissemination, stemness... Read more
    J Cancer Metastasis Treat 2017;3:150-60. | doi:10.20517/2394-4722.2017.38
    Published on: 21 Aug 2017  | Viewed:699  | Downloaded:57
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  • Case Report|Open Access

    Uterine large cell neuroendocrine carcinoma with unusual colonic metastasis

    Antonio Ieni , Giuseppe Angelico , Rosalba De Sarro , Francesco Fleres , Antonio Macrì , Giovanni Tuccari
    A 78-year-old female patient arrived at our practice complaining of progressive abdominal increase and presenting a clinical picture of intestinal obstruction. At physical examination, the abdomen appeared distended, moderately painful with the presence of a mass of hard consistency. Abdominal... Read more
    J Cancer Metastasis Treat 2017;3:144-9. | doi:10.20517/2394-4722.2017.15
    Published on: 16 Aug 2017  | Viewed:392  | Downloaded:36
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  • Case Report|Open Access

    Large chest wall fibromatosis with challenging treatment plan

    Rashi Agrawal , Prekshi Choudhary , Arun Kumar Goel , Vaishali Zamre , Sandeep Agarwal , Dinesh Singh
    The primary mode of treatment for desmoid tumors is surgical excision. However, high recurrence rates (39-79%) have been reported when surgery is used alone. The role of adjuvant radiotherapy after surgical resection of primary disease is controversial and should be based on a balanced discussion... Read more
    J Cancer Metastasis Treat 2017;3:139-43. | doi:10.20517/2394-4722.2017.02
    Published on: 21 Jul 2017  | Viewed:480  | Downloaded:59
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  • Review|Open Access

    Role of adenosine in tumor progression: focus on A2B receptor as potential therapeutic target

    Claudia Sorrentino , Silvana Morello
    Adenosine receptors are a family of G-coupled receptors which mediate the anti-inflammatory and immune-suppressive effects of adenosine in a damaged tissue. A large number of evidence indicate that the accumulation of adenosine under hypoxic conditions favors tumor progression, helping cancer... Read more
    J Cancer Metastasis Treat 2017;3:127-38. | doi:10.20517/2394-4722.2017.29
    Published on: 17 Jul 2017  | Viewed:1293  | Downloaded:141
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  • Topic: Cancer Immunotherapy|Open Access

    Systemic humoral responses of non-muscle-invasive bladder cancer during BCG treatment: less is more

    Fernando M. Calais da Silva , Paula A. Videira , Dário Ligeiro , Maria Guadalupe Cabral , Richard Sylvester , Fernando E. Calais da Silva , Hélder Trindade
    Aim: Intravesical Bacille Calmette-Guérin (BCG) is the mainstay adjuvant treatment of non-muscle-invasive bladder cancer. However, one third of the patients on BCG regimen relapse within the first year of treatment. This study aimed at identifying biomarkers to predict response to BCG treatment.... Read more
    J Cancer Metastasis Treat 2017;3:116-26. | doi:10.20517/2394-4722.2017.25
    Published on: 14 Jul 2017  | Viewed:774  | Downloaded:38
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  • Short Communication|Open Access

    Management of choroidal metastasis using external beam radiotherapy: a retrospective study and review of the literature

    Zakaria Ahmed Youbi , Enachescu Ciprian , Caraivan Ionela , Bennani Zineb , Khounigere Majdouline , Kotzki Léa , Pialat Pierre-Marie , Sesques Pierre , Yossi Séna
    Aim: Choroidal metastases are rare in the evolution of solid cancers and constitute exceptional metastatic sites involving functional visual prognosis. The authors conducted a retrospective study to determine the interest of external radiotherapy for the treatment of choroidal metastases.... Read more
    J Cancer Metastasis Treat 2017;3:105-10. | doi:10.20517/2394-4722.2017.07
    Published on: 30 Jun 2017  | Viewed:457  | Downloaded:63
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  • Case Report|Open Access

    Report of primary leiomyosarcoma of renal pelvis and literature review

    Abhidha Malik , Ritesh Kumar , Abhishek Shankar , Sunil Chumber , Sameer Bakhshi , Seema Kaushal , Bala Thirunavukkarasu
    Primary sarcomas of kidney are exceptionally rare tumors, accounting for only 1-2% of all malignant tumors of kidney. Leiomyosarcoma (LMS) is the most common histological subtype among all renal sarcomas. The authors describe here a case of primary leiomyosarcoma of renal pelvis in a 50-year-old... Read more
    J Cancer Metastasis Treat 2017;3:111-5. | doi:10.20517/2394-4722.2017.12
    Published on: 30 Jun 2017  | Viewed:358  | Downloaded:28
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  • Original Article|Open Access

    Impact of health care insurance on overall survival of patients with multiple myeloma and monoclonal gammopathy of undetermined significance

    Srinivas S. Devarakonda , Runhua Shi , Ellen Friday , Reinhold Munker , Jonathan Glass , Francesco Turturro
    Aim: Health care insurance improves access to care and thus outcome in patients with solid tumors. Little information on the impact of health care insurance on hematological malignancies including multiple myeloma exists. The authors aimed to analyze the effect of health care insurance on the... Read more
    J Cancer Metastasis Treat 2017;3:100-4. | doi:10.20517/2394-4722.2017.19
    Published on: 9 Jun 2017  | Viewed:907  | Downloaded:58
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  • Original Article|Open Access

    Combination of insulin-like growth factor-1, IGF binding protein-3, chromogranin A and prostate specific antigen can improve the detection of prostate cancer

    Saleh Ahmed Kamaleldin Saleh , Heba Mohamed Adly , Anmar Mohammed Nassir
    Aim: Prostate cancer (PCa) is the second most prevalent male cancer worldwide and designated the sixth most frequent male cancer in Arab countries. Although prostate specific antigen (PSA) has become the best and most valuable biomarker for screening of PCa, elevated levels of PSA can reflect the... Read more
    J Cancer Metastasis Treat 2017;3:82-9. | doi:10.20517/2394-4722.2017.20
    Published on: 24 May 2017  | Viewed:982  | Downloaded:51
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  • Original Article|Open Access

    Real-time quantitative PCR array to study drug-induced changes of gene expression in tumor cell lines

    Stefano Amatori , Giuseppe Persico , Mirco Fanelli
    Aim: Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) is still the “gold standard” for quantitative analysis of mRNA and the study of differentially expressed genes. Methods: The authors describe a RT-qPCR array that exploits SYBR Green dye-based detection to perform... Read more
    J Cancer Metastasis Treat 2017;3:90-9. | doi:10.20517/2394-4722.2017.22
    Published on: 24 May 2017  | Viewed:1106  | Downloaded:95
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  • Commentary|Open Access

    A new twist to neurotransmitter receptors and cancer

    Hildegard M. Schuller
    J Cancer Metastasis Treat 2017;3:71-7. | doi:10.20517/2394-4722.2017.18
    Published on: 28 Apr 2017  | Viewed:1280  | Downloaded:92
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  • Case Report|Open Access

    Chest wall metastasis in squamous cell carcinoma of buccal mucosa

    Jayesh Shyamnandan Singh , Ashutosh Das Sharma
    Metastases from head and neck cancers is rare occurrence. The common form of failure/recurrence in these cancers are local site recurrence or nodal metastases. Distant metastases are very rare and are most commonly seen in the lung, brain, liver and bones, and the latent period between the... Read more
    J Cancer Metastasis Treat 2017;3:78-81. | doi:10.20517/2394-4722.2017.08
    Published on: 28 Apr 2017  | Viewed:520  | Downloaded:57
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  • Original Article|Open Access

    Expression of PANDA, LincRNA-p21, PUMA in lung tissues of lung cancer patients in the Xuanwei and non-Xuanwei areas of Yunnan Province

    Kai-Yun Yang , Zhi-Qiang Shen , Yue-Feng He , Kushal Rizal , Hui Tan , An-Ning Chen , Yun-Chao Huang , Guang-Qiang Zhao , Yu-Jie Lei
    Aim: To study the expression of PANDA, LincRNA-p21, and PUMA in lung tissue of patients with lung cancer from Xuanwei of Yunnan Province. Methods: Forty-five cases of lung cancer patients from Xuanwei and 42 lung cancer cases from non-Xuanwei were enrolled. Extraction of RNA was done using the... Read more
    J Cancer Metastasis Treat 2017;3:65-70. | doi:10.20517/2394-4722.2016.65
    Published on: 27 Mar 2017  | Viewed:676  | Downloaded:81
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  • Review|Open Access

    DNA damage-induced nuclear factor-kappa B activation and its roles in cancer progression

    Wei Wang , Arul M. Mani , Zhao-Hui Wu
    DNA damage is a vital challenge to cell homeostasis. Cellular responses to DNA damage (DDR) play essential roles in maintaining genomic stability and survival, whose failure could lead to detrimental consequences such as cancer development and aging. Nuclear factor-kappa B (NF-kB) is a family of... Read more
    J Cancer Metastasis Treat 2017;3:45-59. | doi:10.20517/2394-4722.2017.03
    Published on: 27 Mar 2017  | Viewed:1808  | Downloaded:130
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  • Original Article|Open Access

    Percutaneous, computed tomography guided neurolysis using continuous radiofrequency for pain reduction in oncologic patients

    Periklis Zavridis , Maria Tsitskari , Argyro Mazioti , Dimitrios Filippiadis
    Aim: This study evaluates the efficacy and safety of percutaneous computed tomography (CT)-guided neurolysis using continuous radiofrequency for pain reduction in oncologic patients. Methods: Over the course of 16 months, 22 patients underwent radiofrequency neurolysis as palliative therapy for... Read more
    J Cancer Metastasis Treat 2017;3:60-4. | doi:10.20517/2394-4722.2017.04
    Published on: 27 Mar 2017  | Viewed:406  | Downloaded:46
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  • Review|Open Access

    Cytogenetic and molecular basis of BCR-ABL myelodysplastic syndrome: diagnosis and prognostic approach

    Mostafa Paridar , Omid Kiani Ghalesardi , Mohammad Seghatoleslami , Ahmad Ahmadzadeh , Abbas Khosravi , Najmaldin Saki
    Myelodysplastic syndromes (MDS) include a heterogeneous group of blood disorders generally afflicting older people. Several genetic factors have been reported from these patients that have an important role in the diagnosis, prognosis, and treatment of this disease. BCR-ABL1 is a genetic factor... Read more
    J Cancer Metastasis Treat 2017;3:38-44. | doi:10.20517/2394-4722.2016.61
    Published on: 28 Feb 2017  | Viewed:1055  | Downloaded:122
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  • Topic: Circulating Tumor Cells: Diagnostics and Clinical Applications|Open Access

    A versatile method for enumeration and characterization of circulating tumor cells from patients with breast cancer

    Ujjwala M. Warawdekar , Vani Parmar , Aruna Prabhu , Abhay Kulkarni , Meenal Chaudhari , Rajendra A. Badwe
    Aim: To establish a standardized protocol for the isolation and enumeration of circulating tumor cells (CTCs) from peripheral blood of patients with metastatic breast cancer. Methods: The protocol used tumor cells spiked in a lymphoid cell line with detection by flow cytometry and quantitative... Read more
    J Cancer Metastasis Treat 2017;3:23-33. | doi:10.20517/2394-4722.2016.66
    Published on: 23 Feb 2017  | Viewed:1616  | Downloaded:112
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  • Case Report|Open Access

    Alkaline phosphatase flare with hyperostosis of bone metastases in lung adenocarcinoma treated with gefitinib

    Hiroto Kaneko , Kazuho Shimura , Yosuke Matsumoto , Mihoko Yoshida , Masafumi Taniwaki , Junya Kuroda
    Alkaline phosphatase (ALP) flare has been reported to occur during cancer treatment as a favorable event, particularly in the presence of bone metastasis. There have been only a few reports in lung cancer and associated radiographic findings have seldom been described. The authors observed ALP... Read more
    J Cancer Metastasis Treat 2017;3:34-7. | doi:10.20517/2394-4722.2016.70
    Published on: 23 Feb 2017  | Viewed:643  | Downloaded:64
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  • Topic: Circulating Tumor Cells: Diagnostics and Clinical Applications|Open Access

    Lung cancer biopsy dislodges tumor cells into circulating blood

    Noriyoshi Sawabata , Tomotaka Kitamura , Yuko Nitta , Tomoyo Taketa , Takeshi Ohno , Tatsuya Fukumori , Takeru Hyakutake , Takahito Nakamura
    Aim: A “seed” of lung cancer metastasis is circulating tumor cells (CTCs), which may be dislodged from a tumor during biopsy. This possibility was assessed among patients who underwent lung tumor biopsy using flexible fiber-topic bronchoscopy (FFB). Methods: The study involved six patients with... Read more
    J Cancer Metastasis Treat 2017;3:16-20. | doi:10.20517/2394-4722.2016.67
    Published on: 23 Jan 2017  | Viewed:881  | Downloaded:109
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  • Topic: Circulating Tumor Cells: Diagnostics and Clinical Applications|Open Access

    Profiling of circulating tumor cells in liquid biopsies from metastatic cancer patients

    Pravin D. Potdar , Keerti Sen
    Aim: Circulating tumor cells (CTCs) are crucial to tumor metastasis and valuable for prediction of clinical outcome in patients with solid tumors. Here, the authors aimed to establish a method for enumeration and characterization of CTCs from liquid biopsies. Methods: Peripheral blood mononuclear... Read more
    J Cancer Metastasis Treat 2017;3:6-15. | doi:10.20517/2394-4722.2016.53
    Published on: 23 Jan 2017  | Viewed:1184  | Downloaded:122
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  • Letter to Editor|Open Access

    Use of a dedicated day care unit in a modern radiation oncology facility -- a short audit

    Tejinder Kataria , Susovan Banerjee , Nimesh Dahima , Deepak Gupta , Trinanjan Basu , Shikha Goyal
    J Cancer Metastasis Treat 2017;3:21-2. | doi:10.20517/2394-4722.2016.73
    Published on: 23 Jan 2017  | Viewed:710  | Downloaded:65
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  • Topic: Circulating Tumor Cells: Diagnostics and Clinical Applications|Open Access

    Circulating tumor cells: hope to diagnose and treat metastatic cancer

    Pravin D. Potdar
    J Cancer Metastasis Treat 2017;3:1-5. | doi:10.20517/2394-4722.2016.72
    Published on: 12 Jan 2017  | Viewed:904  | Downloaded:103
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  • Review|Open Access

    Targeting Toll-like receptors against cancer

    Bing Du , Qiu-Li Jiang , Joseph Cleveland , Bing-Rong Liu , Dekai Zhang
    The discovery of Toll-like receptors (TLRs) about 20 years ago was a remarkable achievement not only in the field of immunology but also in the field of medicine. The TLRs are a family of pattern recognition receptors which play an important role in immune responses by recognizing... Read more
    J Cancer Metastasis Treat 2016;2:463-70. | doi:10.20517/2394-4722.2016.62
    Published on: 29 Dec 2016  | Viewed:3258  | Downloaded:316
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  • Original Article|Open Access

    ERCC1 expression in patients with colorectal cancer: a pilot study

    Kinjal K. Gajjar , Deep Kumari Yadav , Toral P. Kobawala , Trupti I. Trivedi , Hemangini H. Vora , Nandita R. Ghosh
    Aim: Excision repair cross complementation group 1 (ERCC1) has a key role in enhanced DNA damage repair caused by oxaliplatin-based therapy and may lead to resistance of these platinum drugs in colorectal cancer (CRC) patients. Hence, the present preliminary study aimed to explore the role of... Read more
    J Cancer Metastasis Treat 2016;2:471-6. | doi:10.20517/2394-4722.2016.52
    Published on: 29 Dec 2016  | Viewed:832  | Downloaded:120
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  • Topic: Circulating Tumor Cells: Diagnostics and Clinical Applications|Open Access

    The significance and clinical utility of the detection of primary malignant circulating prostate cells: a review of the evidence

    Nigel P. Murray
    Primary malignant circulating prostate cells (CPCs) are those detected in blood before definitive treatment for prostate cancer. CPCs can be detected in men with benign prostate disease; however, some methods to distinguish between benign and malignant prostate cells have to be validated. This... Read more
    J Cancer Metastasis Treat 2016;2:453-62. | doi:10.20517/2394-4722.2016.55
    Published on: 16 Dec 2016  | Viewed:639  | Downloaded:91
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  • Topic: Circulating Tumor Cells: Diagnostics and Clinical Applications|Open Access

    Insights into mechanisms of tumor dissemination from circulating tumor cell lines of small cell lung cancer

    Gerhard Hamilton , Barbara Rath
    Despite the fact that the majority of cancer patients succumb to metastatic disease, most aspects of tumor metastasis are not understood in detail at present. Cell biologic steps of dissemination are difficult to characterize in human tumors and research is in large part confined to cell line and... Read more
    J Cancer Metastasis Treat 2016;2:446-52. | doi:10.20517/2394-4722.2016.57
    Published on: 16 Dec 2016  | Viewed:3310  | Downloaded:146
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  • Original Article|Open Access

    Nibrin expression in oral squamous cell carcinoma: association with clinicopathological parameters

    Jigna H. Dave , Hemangini H. Vora , Trupti I. Trivedi , Nandita R. Ghosh
    Aim: The present study sought to discover the role of Nibrin protein in 100 patients with oral squamous cell carcinoma (OSCC) and its potential relationship with clinicopathological parameters. Methods: Nibrin expression was evaluated immunohistochemically using the modified H-score method.... Read more
    J Cancer Metastasis Treat 2016;2:436-42. | doi:10.20517/2394-4722.2015.82
    Published on: 25 Nov 2016  | Viewed:672  | Downloaded:99
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  • Case Report|Open Access

    Squamous cell carcinoma of tongue 18 years after renal transplantation: a case report

    Jyoti Poddar , Ashutosh Das Sharma , Ubrangala Suryanarayana Kunikullaya
    Solid organ transplant recipients are at increased risk of developing malignancies, even decades after transplant, due to the prolonged use of immunosuppressant drugs. A 35-year-old male underwent renal transplant for end stage renal disease 18 years previously and was on immunosuppressive drugs... Read more
    J Cancer Metastasis Treat 2016;2:443-5. | doi:10.20517/2394-4722.2016.36
    Published on: 25 Nov 2016  | Viewed:661  | Downloaded:91
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  • Meeting Abstracts|Open Access

    Obergurgl Research Conference Abstracts on "Cancer Stem Cells: Impact on Treatment"

    Ira-Ida Skvortsova
    J Cancer Metastasis Treat 2016;2:417-35. | doi:10.20517/2394-4722.2016.58
    Published on: 16 Nov 2016  | Viewed:701  | Downloaded:117
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  • Review|Open Access

    Nanocarrier drugs in the treatment of brain tumors

    Tereza Cerna , Marie Stiborova , Vojtech Adam , Rene Kizek , Tomas Eckschlager
    Nanoparticle-mediated targeted delivery of drugs might significantly reduce the dosage and optimize their release properties, increase specificity and bioavailability, improve shelf life, and reduce toxicity. Some nanodrugs are able to overcome the blood-brain barrier that is an obstacle to... Read more
    J Cancer Metastasis Treat 2016;2:407-16. | doi:10.20517/2394-4722.2015.95
    Published on: 31 Oct 2016  | Viewed:2505  | Downloaded:285
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  • Original Article|Open Access

    Sunitinib effectiveness and safety as first line treatment in metastatic renal cell carcinoma, in the Costa Rican population

    Esteban Gonzalez , Silvia Alfaro , Allan Ramos-Esquivel , Denis Ulises Landaverde
    Aim: Tyrosine kinase inhibitors are part of the armamentarium to treat metastatic renal cell carcinomas (mRCC). Costa Rica has approved sunitinib in the first line setting. The authors conducted a retrospective study to address the effectiveness and safety profile of sunitinib in our population... Read more
    J Cancer Metastasis Treat 2016;2:396-401. | doi:10.20517/2394-4722.2016.27
    Published on: 21 Oct 2016  | Viewed:1711  | Downloaded:163
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  • Case Report|Open Access

    Metastatic clostridial myonecrosis secondary to perforated metastatic bowel cancer

    Nasser Mohammed Amer , John Karayanis
    Spontaneous metastatic clostridial myonecrosis is a rare condition caused by Clostridium septicum. The underlying lesion is usually either a colonic neoplasm or leukemia. The authors reported a 67-year-old female who presented with acute abdomen secondary to a perforated sigmoid cancer and who... Read more
    J Cancer Metastasis Treat 2016;2:402-6. | doi:10.20517/2394-4722.2016.16
    Published on: 21 Oct 2016  | Viewed:1048  | Downloaded:82
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  • Case Report|Open Access

    Isolated breast metastasis mimicking as second primary cancer - a case report

    Manjari Shah , Umang Mithal , Sandeep Agarwal , Sweety Gupta , Disha Tiwari , Shashank Srinivasan , Asheesh Jain , Ritu Chandra
    Primary carcinoma of breast is common but breast is a rare site of metastasis and metastases from extramammary sites are even rarer. Metastasis to breast from rectal carcinoma is very unusual and till now 19 cases of breast secondaries from colorectal carcinoma have been reported in literature... Read more
    J Cancer Metastasis Treat 2016;2:391-5. | doi:10.20517/2394-4722.2016.22
    Published on: 30 Sep 2016  | Viewed:890  | Downloaded:96
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  • Case Report|Open Access

    A small solitary fibrous tumor of the bladder

    Guido Petracco , Carlo Patriarca
    The authors present a case of histologically benign and incidentally discovered millimetric solitary fibrous tumor of the bladder, invisible to radiologic imaging and clinically benign. The case came to our attention because of repeated episodes of renal colic. As opposed to the present case,... Read more
    J Cancer Metastasis Treat 2016;2:388-90. | doi:10.20517/2394-4722.2016.21
    Published on: 30 Sep 2016  | Viewed:710  | Downloaded:76
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  • Original Article|Open Access

    Do elderly NSCLC stage IV patients benefit from chemotherapy as well as younger? An analysis from clinical practice date

    Regina Gironés , Pedro López , Rebeca Chulvi , Mamen Cañabate
    Aim: The aim of this study was to evaluate the efficacy of treatment related to age in metastatic non-small cell lung cancer (NSCLC). We compared young and elders (> 70) in the setting of a regional Spanish hospital. We hypothesized that elder benefit as much as younger patients from... Read more
    J Cancer Metastasis Treat 2016;2:379-87. | doi:10.20517/2394-4722.2016.20
    Published on: 30 Sep 2016  | Viewed:1093  | Downloaded:88
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  • Review|Open Access

    Function of cancer cell-derived extracellular matrix in tumor progression

    Gao-Feng Xiong , Ren Xu
    Extracellular matrix (ECM) is an essential component of the tumor microenvironment. Cancer development and progression are associated with increased ECM deposition and crosslink. The chemical and physical signals elicited from ECM are necessary for cancer cell proliferation and invasion. It is... Read more
    J Cancer Metastasis Treat 2016;2:357-64. | doi:10.20517/2394-4722.2016.08
    Published on: 18 Sep 2016  | Viewed:11712  | Downloaded:468
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  • Review|Open Access

    The features of peritoneal metastases from gastric cancer

    Gianni Mura , Beatrice Verdelli
    Peritoneal Carcinomatosis (PC) from metastasization of Gastric Cancer (GC), either present at first diagnosis of GC or as recurrence, is considered a fatal disease with no hope of definitive cure. Although newer agents like S1 and docetaxel have shown some promise, the median overall survival... Read more
    J Cancer Metastasis Treat 2016;2:365-74. | doi:10.20517/2394-4722.2016.19
    Published on: 18 Sep 2016  | Viewed:5232  | Downloaded:336
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  • Case Report|Open Access

    Pediatric gliomatosis cerebri presenting with intratumoral hemorrhage leading to poor outcome

    Hiromasa Adachi , Masashi Kitagawa , Toshinari Kawasaki , Takafumi Wataya
    Gliomatosis cerebri (GC) is an uncommon disease, defined as diffuse infiltration of neoplastic glial cells involving at least three cerebral lobes. GCs in young population are rare. We described a case of 14-year-old woman with GC who did not receive any recommended treatment, because the... Read more
    J Cancer Metastasis Treat 2016;2:375-8. | doi:10.20517/2394-4722.2016.33
    Published on: 18 Sep 2016  | Viewed:718  | Downloaded:83
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  • Topic: Neuroendocrine Tumors|Open Access

    Circulating neuroendocrine tumors biomarkers. Why? When? How? Suggestions for clinical practice from guidelines and consensus

    Paola Razzore , Giorgio Arnaldi
    Neuroendocrine neoplasms (NETs) are rare tumors that are increasing in incidence. NETs are characterized by heterogeneous biological behaviour, clinical presentation and course. A sensitive and specific diagnostic and prognostic circulating biomarker useful for all sites, grading and staging of... Read more
    J Cancer Metastasis Treat 2016;2:348-56. | doi:10.20517/2394-4722.2016.39
    Published on: 31 Aug 2016  | Viewed:2020  | Downloaded:283
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  • Topic: Neuroendocrine Tumors|Open Access

    Pancreatic neuroendocrine tumor with hypoglycemia and elevated insulin-like growth factor II: a case report

    Roberta Modica , Antonella Di Sarno , Annamaria Colao , Antongiulio Faggiano
    Pancreatic neuroendocrine tumors (pNETs) can be associated with different clinical syndromes. Insulinoma is the most common functioning pNET characterized by hypoglycemia and hyperinsulinemia. The authors report a case of a man presenting with hypoglycemia and biochemical features of insulinoma.... Read more
    J Cancer Metastasis Treat 2016;2:345-7. | doi:10.20517/2394-4722.2016.44
    Published on: 31 Aug 2016  | Viewed:704  | Downloaded:128
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  • Topic: Neuroendocrine Tumors|Open Access

    Orbital lesions, an exceedingly rare site of neuroendocrine tumor metastasis

    Sara Pusceddu , Massimo Milione , Silvia Ortolani , Alessio Pellegrinelli , Marco Brugia , Filippo de Braud , Lorenzo Antonuzzo
    Neuroendocrine tumors are rare neoplasms arising primarily in the gastrointestinal tract and lung. The liver is the most common site of metastases, but these tumors can rarely metastasize to atypical sites. Surgery is the only curative approach while the optimal medical treatment is debated. From... Read more
    J Cancer Metastasis Treat 2016;2:341-4. | doi:10.20517/2394-4722.2016.41
    Published on: 31 Aug 2016  | Viewed:875  | Downloaded:106
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  • Topic: Neuroendocrine Tumors|Open Access

    Medical therapy for advanced gastro-entero-pancreatic and bronchopulmonary neuroendocrine tumors

    Mariangela Torniai , Silvia Rinaldi , Francesca Morgese , Giulia Ricci , Azzurra Onofri , Christian Grohé , Rossana Berardi
    Neuroendocrine tumors (NETs) represent a spectrum of rare neoplasms arising in different organism sites. Depending on the site of onset, they also can be distinguished using lab exams (secreting vs. nonsecreting), clinical symptoms (functioning vs. nonfunctioning), behavioral, morphological... Read more
    J Cancer Metastasis Treat 2016;2:329-40. | doi:10.20517/2394-4722.2016.47
    Published on: 31 Aug 2016  | Viewed:2134  | Downloaded:143
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  • Topic: Neuroendocrine Tumors|Open Access

    Double tracer PET/CT: what is it and what does it mean?

    Mattia Pellicciari , Silvia Ortolani , Elisabetta Grego , Giampaolo Tortora , Sara Cingarlini
    68Ga-DOTA-peptide PET/CT is a recommended imaging modality in the workup of neuroendocrine neoplasms (NENs), which shows high diagnostic sensitivity and is a strong predictor of successful somatostatin receptor directed treatments. Although not routinely recommended, reliable evidences show that... Read more
    J Cancer Metastasis Treat 2016;2:321-8. | doi:10.20517/2394-4722.2016.45
    Published on: 31 Aug 2016  | Viewed:588  | Downloaded:102
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  • Topic: Neuroendocrine Tumors|Open Access

    Review of recent advances in medical treatment for neuroendocrine neoplasms: somatostatin analogs and chemotherapy

    Francesca Spada , Monica Valente
    Neuroendocrine neoplasms (NENs) are a heterogeneous group of rare tumours often producing high levels of hormones and causing symptoms. There are a number of different types of NENs. They usually arise as advanced and low/intermediate grade only in a minority of cases, as high grade. Treatment... Read more
    J Cancer Metastasis Treat 2016;2:313-20. | doi:10.20517/2394-4722.2016.38
    Published on: 31 Aug 2016  | Viewed:6091  | Downloaded:301
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  • Topic: Neuroendocrine Tumors|Open Access

    Merkel cell carcinoma responsive to Etoposide: a case report and brief literature review

    Chiara Ancona , Andrea Caff , Giovanni Manfredi Assanto , Stefano Cordio
    Merkel cell carcinoma (MCC), first described in 1972, is an aggressive primary cutaneous carcinoma able to incorporate both epithelial and neuroendocrine features. MCC mainly appears in individuals in their eighth decade and it is related to a high mortality rate. The etiology of this rare... Read more
    J Cancer Metastasis Treat 2016;2:310-2. | doi:10.20517/2394-4722.2016.46
    Published on: 17 Aug 2016  | Viewed:1217  | Downloaded:82
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  • Topic: Neuroendocrine Tumors|Open Access

    Controversies in the treatment of digestive neuroendocrine tumors

    Maria Rinzivillo , Francesco Panzuto , Gianfranco Delle Fave
    Gastroenteropancreatic neuroendocrine tumors (NETs) have an incidence of 2.39 per 100,000 inhabitants per year, and a prevalence of 35 cases per 100,000 inhabitants; the gap between these rates is due to the relatively long survival time of these tumors, which can be thus considered as chronic... Read more
    J Cancer Metastasis Treat 2016;2:304-9. | doi:10.20517/2394-4722.2016.40
    Published on: 17 Aug 2016  | Viewed:629  | Downloaded:115
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  • Topic: Neuroendocrine Tumors|Open Access

    Management of hepatic metastases of well/moderately differentiated neuroendocrine tumors of the digestive tract

    Anna La Salvia , Stefano Partelli , Marco Tampellini , Domenico Tamburrino , Massimo Falconi , Giorgio V. Scagliotti , Maria Pia Brizzi
    In neuroendocrine tumors (NETs), liver metastases (LM) represent the most crucial prognostic factor, irrespective of the primary tumor site. At diagnosis, about 65-95% of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) show hepatic metastasis. Management strategies of LM are heterogeneous... Read more
    J Cancer Metastasis Treat 2016;2:294-303. | doi:10.20517/2394-4722.2016.37
    Published on: 17 Aug 2016  | Viewed:1114  | Downloaded:196
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  • Topic: Neuroendocrine Tumors|Open Access

    Neuroendocrine tumors: current therapies, notch signaling, and cancer stem cells

    Judy S. Crabtree , Lucio Miele
    Neuroendocrine tumors (NETs) encompass a broad spectrum of malignancies all derived from neuroendocrine cell lineage, affecting many different organs including the gastrointestinal (GI) tract, the endocrine pancreas, the thyroid, the skin and the respiratory tract. These tumors as a group are... Read more
    J Cancer Metastasis Treat 2016;2:279-93. | doi:10.20517/2394-4722.2016.30
    Published on: 17 Aug 2016  | Viewed:1379  | Downloaded:244
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  • Topic: Neuroendocrine Tumors|Open Access

    Neuroendocrine tumors: a multidisciplinary approach for a complex disease

    Rossana Berardi
    J Cancer Metastasis Treat 2016;2:277-8. | doi:10.20517/2394-4722.2016.50
    Published on: 17 Aug 2016  | Viewed:2127  | Downloaded:174
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  • Original Article|Open Access

    Oxidative stress and breast cancer biomarkers: the case of the cytochrome P450 2E1

    Subir Singh , Ramkumar Rajendran , Kengo Kuroda , Emiko Isogai , Marija Krstic-Demonacos , Constantinos Demonacos
    Aim: The aim of the study is to investigate the impact of the cytochrome P450 2E1, which is the most efficient CYP450 family member in generating reactive oxygen species (ROS), on cellular energy metabolism of breast cancer cells and therefore the effects of CYP2E1 on breast carcinogenesis.... Read more
    J Cancer Metastasis Treat 2016;2:268-76. | doi:10.20517/2394-4722.2016.42
    Published on: 29 Jul 2016  | Viewed:2778  | Downloaded:275
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  • Original Article|Open Access

    Evaluation of anti-metastatic effect of chitosan nanoparticles on esophageal cancer-associated fibroblasts

    Pravin D. Potdar , Aashutosh U. Shetti
    Aim: Esophageal cancer is one of the major types of cancers, causing death of approximately 5% of all cancer deaths. This is due, in large part, to both relatively ineffectual and unavailable treatment. In order to develop an effective treatment strategy against esophageal cancer, it is important... Read more
    J Cancer Metastasis Treat 2016;2:259-67. | doi:10.20517/2394-4722.2016.25
    Published on: 29 Jul 2016  | Viewed:1750  | Downloaded:146
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  • Case Report|Open Access

    Malignant eccrine acrospiroma with nodal and bone metastasis

    Burhan Wani , Shiekh Aejaz Aziz , Mohmad Hussain Mir , Gull Mohammad Bhat , Abdul Rashid Lone
    Acrospiromas are cutaneous tumors of sweat duct differentiation. Although various eccrine sweat gland tumours including benign acrospiroma are widely reviewed, malignant acrospiroma is rarely reported. Clinically, they resemble other cutaneous lesions and the primary treatment is wide local... Read more
    J Cancer Metastasis Treat 2016;2:255-8. | doi:10.20517/2394-4722.2015.92
    Published on: 20 Jul 2016  | Viewed:1196  | Downloaded:81
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  • Case Report|Open Access

    EGFR mutation--a commonly neglected mutation in squamous cell lung carcinoma

    Rajeev Saini , Ullas Batra , Akhil Jain , Chaturbhuj Agrawal
    Lung cancer is the leading cause of cancer-related death worldwide. Advances in molecular biology have unveiled various targetable mutations with epidermal growth factor receptor (EGFR) being most common. EGFR testing is recommended for all locally advanced or metastatic adenocarcinoma lungs but... Read more
    J Cancer Metastasis Treat 2016;2:253-4. | doi:10.20517/2394-4722.2016.07
    Published on: 20 Jul 2016  | Viewed:1380  | Downloaded:144
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  • Topic: Cancer Stem Cells: Impact on Treatment|Open Access

    Curcumin sensitizes quiescent leukemic cells to antimitotic drug 5-fluorouracil by inducing proliferative responses in them

    Anagha Gardane , Mariyah Poonawala , Anuradha Vaidya
    Long-term quiescence or dormancy is a fundamental feature of cancer stem cells (CSCs) that are genetically identical to the malignant clone but constitute the only cells with tumor propagation potential within the overall tumor population. These quiescent cells show significant resistance to... Read more
    J Cancer Metastasis Treat 2016;2:245-52. | doi:10.20517/2394-4722.2016.11
    Published on: 8 Jul 2016  | Viewed:2075  | Downloaded:202
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  • Topic: Cancer Stem Cells: Impact on Treatment|Open Access

    The quintessential quiescence of cancer stem cells: a struggle towards better treatment

    Anuradha Vaidya
    J Cancer Metastasis Treat 2016;2:243-4. | doi:10.20517/2394-4722.2016.10
    Published on: 8 Jul 2016  | Viewed:598  | Downloaded:133
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  • Topic: Cancer Stem Cells: Impact on Treatment|Open Access

    Therapeutic strategies for targeting cancer stem cells

    Yu Jeong Kim , Elizabeth L. Siegler , Natnaree Siriwon , Pin Wang
    The therapeutic limitations of conventional chemotherapeutic drugs present a challenge for cancer therapy; these shortcomings are largely attributed to the ability of cancer cells to repopulate and metastasize after initial therapies. Compelling evidence suggests that cancer stem cells (CSCs)... Read more
    J Cancer Metastasis Treat 2016;2:233-42. | doi:10.20517/2394-4722.2016.26
    Published on: 8 Jul 2016  | Viewed:8892  | Downloaded:882
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  • Topic: Cancer Stem Cells: Impact on Treatment|Open Access

    Introduction to the Special Issue “Cancer Stem Cells: Impact on Treatment”

    Ira-Ida Skvortsova
    J Cancer Metastasis Treat 2016;2:231-2. | doi:10.20517/2394-4722.2016.35
    Published on: 8 Jul 2016  | Viewed:789  | Downloaded:153
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  • Review|Open Access

    Changing paradigm in treatment of lung cancer

    Sundaram Viswanath , Abhishek Pathak , Amul Kapoor , Anvesh Rathore , Bhupendra Nath Kapur
    Lung cancer is one of the most common and deadliest forms of cancer. It accounts for 13% of all new cancer cases and 19% of cancer-related deaths. In India, lung cancer constitutes 6.9% of all new cancer cases and 9.3% of all cancer cases. There has also been a dramatic rise worldwide in both the... Read more
    J Cancer Metastasis Treat 2016;2:214-9. | doi:10.20517/2394-4722.2015.88
    Published on: 15 Jun 2016  | Viewed:719  | Downloaded:204
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  • Case Report|Open Access

    Carcinoma cervix with fat attenuating skull metastases

    Anuradha Kapali , Atmakuri Sateesh Kumar , Mukunda Malathi , S. D. Shamsundar
    Skeletal metastasis in carcinoma cervix occurs in about 0.8-23% of cases. These lesions are usually radiographically lytic. Very few cases of metastases to the skull have been identified, about 5 cases to the best of our knowledge. We present a case of adenosquamous cell carcinoma of cervix with... Read more
    J Cancer Metastasis Treat 2016;2:228-30. | doi:10.20517/2394-4722.2015.87
    Published on: 15 Jun 2016  | Viewed:1314  | Downloaded:89
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  • Review|Open Access

    The role of human papillomaviruses in cancer progression

    Pinar Tulay , Nedime Serakinci
    The importance of human papillomavirus (HPV) infection and its role in the progress of cancer have been widely evaluated. The understanding of HPV association with certain cancers, such as cervical cancer, is very well established. A big step forward in the prevention of HPV associated cancers... Read more
    J Cancer Metastasis Treat 2016;2:201-13. | doi:10.20517/2394-4722.2015.67
    Published on: 15 Jun 2016  | Viewed:2275  | Downloaded:249
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  • Case Report|Open Access

    An unusual case of encapsulated papillary carcinoma of breast

    Kriti Chauhan , Monika Garg
    Intracystic (encapsulated) papillary carcinoma of breast is a rare variant of breast cancer. It is usually a low-grade tumor showing estrogen, progesterone positivity. The authors report an unusual case of intracystic papillary carcinoma showing high nuclear grade, brisk mitosis, and necrosis... Read more
    J Cancer Metastasis Treat 2016;2:224-7. | doi:10.20517/2394-4722.2015.63
    Published on: 15 Jun 2016  | Viewed:4683  | Downloaded:155
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  • Review|Open Access

    Muscarinic receptor signaling and colon cancer progression

    Guofeng Xie , Jean-Pierre Raufman
    Due to the lack of effective treatments, advanced colorectal cancer (CRC) remains a leading cause of cancer death in the United States. Emerging evidence supports the observation that muscarinic receptor (MR) signaling plays a critical role in growth and progression of CRC. MR activation by... Read more
    J Cancer Metastasis Treat 2016;2:195-200. | doi:10.20517/2394-4722.2016.05
    Published on: 15 Jun 2016  | Viewed:4072  | Downloaded:157
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  • Case Report|Open Access

    Osteonecrosis of the jaw in a patient with acute myeloid leukemia, who received azacitidine

    Ourania Nicolatou-Galitis , Dimitra Galiti , Maria Moschogianni , Sotirios Sachanas , Beatrice J. Edwards , Cesar A. Migliorati , Gerassimos Pangalis
    The first case of osteonecrosis of the jaw (ONJ) related to azacitidine therapy was reported. A 64-year-old male with acute myeloid leukemia, who received 5-azacitidine, presented with pain and purulence of the right second premolar. An unsuccessful endodontic therapy resulted in dental... Read more
    J Cancer Metastasis Treat 2016;2:220-3. | doi:10.20517/2394-4722.2016.06
    Published on: 15 Jun 2016  | Viewed:1511  | Downloaded:111
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  • Topic: Brain tumor cell invasion and metastasis: anatomical, biological and clinical considerations|Open Access

    Gemcitabine followed by radiotherapy in treatment of newly diagnosed high-grade gliomas

    Maha El-Naggar , Mervat Omar , Ahmed Elgeriany , Godefridus J. Peters , Amina Mostafa , Samir Shehata
    Aim: High-grade glioblastoma multiforme (GBM) has a poor median overall survival (OS). The standard treatment after surgery is temozolomide and radiotherapy (RTH). Patients with unmethylated methylguanine-methyltransferase promoter (MGMT) have no or little benefit from temozolomide and are... Read more
    J Cancer Metastasis Treat 2016;2:188-94. | doi:10.20517/2394-4722.2016.15
    Published on: 18 May 2016  | Viewed:1502  | Downloaded:179
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  • Topic: Brain tumor cell invasion and metastasis: anatomical, biological and clinical considerations|Open Access

    Targeting cerebrospinal fluid for discovery of brain cancer biomarkers

    Tarek Shalaby , Federica Achini , Michael A. Grotzer
    Central nervous system (CNS) cancer is a devastating illness with unmet therapeutic needs. Establishing biomarkers that have the potential to guide accurate CNS cancer diagnosis or are helpful in predicting disease progression or therapy response is of great interest. Cerebrospinal fluid (CSF)... Read more
    J Cancer Metastasis Treat 2016;2:176-87. | doi:10.20517/2394-4722.2016.12
    Published on: 18 May 2016  | Viewed:14911  | Downloaded:451
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  • Topic: Brain tumor cell invasion and metastasis: anatomical, biological and clinical considerations|Open Access

    Interdisciplinary management of central nervous system metastasis and neoplastic meningitis: recent developments and future perspectives

    Ghazaleh Tabatabai , Marilin Koch , Cristiana Roggia , Juliane Ebert , Claus Garbe , Friedegund Meier , Sara Brucker , Eva Maria Grischke , Diethelm Wallwiener , Robert Möhle , Lothar Kanz , Walter Erich Auletzky , Ulrike Ernemann , Christian LaFougere , Konstantin Nikolaou , Bernd Pichler , Jens Schittenhelm , Manuela Neumann , Falko Fend , Stefan Czemmel , Sven Nahnsen , Frank Paulsen , Daniel Zips , Maike van Lessen , Hans-Otto Karnath , Ulf Ziemann , Hans-Georg Rammensee , Constantin Roder , Marco Skardelly , Jürgen Bernd Honegger , Marcos Tatagiba
    The incidence of metastatic disease in the central nervous system (CNS) is rising. According to current estimates, up to a third of adult cancer patients will suffer from CNS metastasis. Clinical evidence-based data from prospective randomized trials are rare, however, because CNS metastasis... Read more
    J Cancer Metastasis Treat 2016;2:163-75. | doi:10.20517/2394-4722.2016.01
    Published on: 18 May 2016  | Viewed:1735  | Downloaded:125
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  • Topic: Brain tumor cell invasion and metastasis: anatomical, biological and clinical considerations|Open Access

    Dissecting brain tumor growth and metastasis in vitro and ex vivo

    Michael A. Grotzer , Anuja Neve , Martin Baumgartner
    Local infiltration and distal dissemination of tumor cells hamper efficacy of current treatments against central nervous system (CNS) tumors and greatly influence mortality and therapy-induced long-term morbidity in survivors. A number of in vitro and ex vivo assay systems have been established... Read more
    J Cancer Metastasis Treat 2016;2:149-62. | doi:10.20517/2394-4722.2016.02
    Published on: 18 May 2016  | Viewed:8385  | Downloaded:542
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  • Topic: Brain tumor cell invasion and metastasis: anatomical, biological and clinical considerations|Open Access

    Introduction to this special issue on brain tumor cell invasion and metastasis: anatomical, biological and clinical considerations

    Michael A. Grotzer
    It is my privilege to introduce the readers to this special issue entitled “Brain tumor cell invasion and metastasis: anatomical, biological and clinical considerations”. As cancer is a global epidemic which knows no borders, efforts to better understand biology and to control it should know no... Read more
    J Cancer Metastasis Treat 2016;2:147-8. | doi:10.20517/2394-4722.2016.23
    Published on: 18 May 2016  | Viewed:366  | Downloaded:81
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  • Original Article|Open Access

    The association of the uterine motion with bladder volume during radiotherapy in gynecological malignancies

    Bhandari Virendra , Mutneja Abhinav , Gurjar Omprakash , Saadvik Raghuram , Bagdare Priyusha , Gupta Krishnlal , Singh Kanchan
    Aim: This study was performed to assess the extent of interfraction uterine motion during radiotherapy for cervical cancer and uterine body carcinoma while maintaining a strict bladder filling protocol. Methods: Twenty-four patients with cervical cancer or uterine body carcinoma who were treated... Read more
    J Cancer Metastasis Treat 2016;2:139-43. | doi:10.20517/2394-4722.2015.68
    Published on: 15 Apr 2016  | Viewed:2076  | Downloaded:175
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  • Case Report|Open Access

    Primary malignant melanoma of the spinal cord: a case report

    Ashutosh Das Sharma , Jyoti Poddar , Ubrangala Suryanarayan Kunikullaya , Jay Prakash Neema
    Primary malignant melanoma of the central nervous system is rare, and the events involving the spinal cord are even more infrequent. A 30-year-old male presented with a mass lesion of the spinal cord. After radiological workup, the mass was resected in December 2012. The histopathological... Read more
    J Cancer Metastasis Treat 2016;2:144-6. | doi:10.20517/2394-4722.2015.58
    Published on: 15 Apr 2016  | Viewed:2199  | Downloaded:121
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  • Original Article|Open Access

    The role of technetium Tc99m-tetrofosmin as head and neck tumor-seeking agent: a preliminary report

    Chrissa Sioka , Thomas Exarchopoulos , Vlasis Skloupiotis , Vaios Papathanassiou , Vasileios Ragos , Maria Argyropoulou , Anna Gousia , Periklis Tsekeris , Georgios Exarchakos , Dimitrios Assimakopoulos , Andreas Fotopoulos
    Aim: To evaluate the diagnostic value of technetium Tc99m-tetrofosmin (99mTc-TF) in primary cancers of the head and neck. Methods: Single photon emission computer tomography with planar imaging of the neck for primary site evaluation and whole body scanning for assessment of metastases in 12... Read more
    J Cancer Metastasis Treat 2016;2:133-8. | doi:10.20517/2394-4722.2015.65
    Published on: 15 Apr 2016  | Viewed:2036  | Downloaded:112
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  • Case Report|Open Access

    Metachronous bladder metastasis from papillary renal cell carcinoma

    Arun Ramdas Menon , Nivedita Suresh , Prajwal Ravinder , Rajeev Thekke Puthalath
    Renal cell carcinoma (RCC) is well known for its metastatic potential and predilection for unusual sites of metastasis. Metastasis to the bladder is rare and has been reported predominantly from clear cell RCC. We report a case of a 72-year-old male presenting with a bladder tumor which on... Read more
    J Cancer Metastasis Treat 2016;2:130-2. | doi:10.4103/2394-4722.169645
    Published on: 28 Mar 2016  | Viewed:1390  | Downloaded:96
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  • Case Report|Open Access

    Metastatic high-grade neuroendocrine tumor of mandible

    Jitender Batra , Chinmay D. Vakade , Sonal Grover , Gyanander Attresh
    Neuroendocrine tumors of the oral cavity and jaws are exceedingly rare. They include paragangliomas, a melanotic neuroectodermal tumor of infants, small cell carcinomas, and Merckel cell carcinomas. Most have been non-functional in nature. Breast, lung, liver, colon, and prostate are the most... Read more
    J Cancer Metastasis Treat 2016;2:127-9. | doi:10.4103/2394-4722.170022
    Published on: 28 Mar 2016  | Viewed:3816  | Downloaded:107
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  • Case Report|Open Access

    Metastatic breast cancer: an unusual cause of diplopia

    Nasser Mohammed Amer , Gareth Bashir , Arikoge Ogedegbe , Ibtisam Saeed
    While secondary solid cancer into the eye orbit is rare, it is the most common site for primary metastasis in female breast cancer. We report a case of a sixty-six years old woman presenting to her optician with complaints of double vision. Magnetic resonance imaging revealed an invasive lesion... Read more
    J Cancer Metastasis Treat 2016;2:123-6. | doi:10.20517/2394-4722.2016.13
    Published on: 28 Mar 2016  | Viewed:2308  | Downloaded:94
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  • Topic: Brain tumor cell invasion and metastasis: anatomical, biological and clinical considerations|Open Access

    Tailored nanocarriers and bioconjugates for combating glioblastoma and other brain tumors

    Fatema ELAmrawy , Amr A. Othman , Chris Adkins , Aliaa Helmy , Mohamed I. Nounou
    Worldwide, the incidence of primary brain tumors is on the rise. Unfortunately, noninvasive drug therapy is hampered by poor access of most drugs to the brain due to the insurmountable blood-brain barrier (BBB). Nanotechnology holds great promise for noninvasive therapy of severe brain diseases.... Read more
    J Cancer Metastasis Treat 2016;2:112-22. | doi:10.20517/2394-4722.2015.78
    Published on: 11 Mar 2016  | Viewed:13616  | Downloaded:731
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  • Topic: Brain tumor cell invasion and metastasis: anatomical, biological and clinical considerations|Open Access

    Effects of Gas1 on gliomas: a review on current preclinical studies

    Jose Segovia , Elizabeth Bautista , Manuel Lara-Lozano
    Glioblastoma multiforme (GBM) is the most common and lethal brain tumor. Its prognosis remains very poor, despite the use of combined treatments such as surgical resection, radiation and chemotherapy. The major limitations for the treatment of GBM are its high invasiveness, tumor recurrence and... Read more
    J Cancer Metastasis Treat 2016;2:101-11. | doi:10.20517/2394-4722.2015.76
    Published on: 11 Mar 2016  | Viewed:2989  | Downloaded:203
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  • Topic: Brain tumor cell invasion and metastasis: anatomical, biological and clinical considerations|Open Access

    Brain infiltration by cancer cells: different roads to the same target?

    Mayra Paolillo , Sergio Schinelli
    Brain infiltration by cancer cells is a complex process in which metastatic cells detached from the primary tumor must firstly survive in the blood flow, cross the blood brain barrier (BBB) and finally colonize a foreign microenvironment. The cells that successfully bypass the cellular barriers... Read more
    J Cancer Metastasis Treat 2016;2:90-100. | doi:10.4103/2394-4722.172661
    Published on: 11 Mar 2016  | Viewed:1297  | Downloaded:212
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  • Topic: Brain tumor cell invasion and metastasis: anatomical, biological and clinical considerations|Open Access

    The role of the PI3K/AKT/mTOR pathway in brain tumor metastasis

    Silvia Crespo , Marcus Kind , Alexandre Arcaro
    The PI3K/AKT/mTOR (PAM) pathway is involved in a variety of cellular functions and often contributes to oncogenesis and cancer progression. It has been recognized that this pathway is frequently activated in the most common central nervous system cancers of adults and children, malignant gliomas... Read more
    J Cancer Metastasis Treat 2016;2:80-9. | doi:10.20517/2394-4722.2015.72
    Published on: 11 Mar 2016  | Viewed:13587  | Downloaded:611
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  • Topic: Brain tumor cell invasion and metastasis: anatomical, biological and clinical considerations|Open Access

    Brain tumor surgery: supplemental intra-operative imaging techniques and future challenges

    Telmo Augusto Barba Belsuzarri , Raphael Martinelli Anson Sangenis , João Flavio Mattos Araujo
    Modern brain tumor surgery stands in the pillar of maximum safe resection. Tumor borders are always challenging, especially infiltration zones in malignant brain tumors. Novel technologies are designed for a better delineation and to increase the extent of resection (EOR) in brain tumor surgery,... Read more
    J Cancer Metastasis Treat 2016;2:70-9. | doi:10.4103/2394-4722.172249
    Published on: 11 Mar 2016  | Viewed:2902  | Downloaded:242
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  • Case Report|Open Access

    Unusual skeletal muscle metastasis from carcinoma cervix

    Mehlam Kausar , Desh Deepak Ladia , Abhinav Mutneja , Virendra Bhandari
    Cervical cancer is the most common malignancy in Indian women. It usually spreads locally or via regional lymphatics to retroperitoneal lymph nodes and hematogenous spread is rare. The occurrence of skeletal muscle metastases is a very rare event and only a few cases have been reported in... Read more
    J Cancer Metastasis Treat 2016;2:67-9. | doi:10.4103/2394-4722.170545
    Published on: 29 Feb 2016  | Viewed:1204  | Downloaded:94
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  • Case Report|Open Access

    The therapeutic potential of duloxetine in prostate cancer-related fatigue

    Rita De Sanctis , Alessandro Viganò
    Cancer-related fatigue (CRF) is a common polysymptomatic syndrome with no standard therapy. The authors present the case of a prostate cancer patient in whom, during hormone therapy, disabling CRF and urinary incontinence occurred. CRF was assessed according to the brief fatigue inventory (BFI).... Read more
    J Cancer Metastasis Treat 2016;2:64-6. | doi:10.4103/2394-4722.164646
    Published on: 29 Feb 2016  | Viewed:608  | Downloaded:80
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  • Original Article|Open Access

    Prognostic factors and efficacy of GDP-R therapy in refractory/relapsed diffuse large B-cell lymphomas not eligible for high-dose therapy

    Francesco Ghio , Giulia Cervetti , Nadia Cecconi , Matteo Pelosini , Sara Galimberti , Riccardo Morganti , Paola Ferrari , Andrea Nicolini , Mario Petrini
    Aim: The main aim of the present study was to evaluate the overall survival (OS) and time to treatment failure (TTF) in a cohort of relapsed/refractory diffuse large B-cell lymphomas (DLBCLs) not eligible for high-dose therapy (HDT) treated with gemcitabine in association with dexamethasone,... Read more
    J Cancer Metastasis Treat 2016;2:59-63. | doi:10.4103/2394-4722.172291
    Published on: 29 Feb 2016  | Viewed:2183  | Downloaded:182
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  • Review|Open Access

    What we have learned from urinary bladder cancer models

    Carina Bernardo , Céu Costa , Carlos Palmeira , Rosário Pinto-Leite , Paula Oliveira , Rui Freitas , Francisco Amado , Lúcio L. Santos
    Urinary bladder cancer (UBC) is a heterogeneous disease with highly variable clinical outcomes and responses to chemotherapy. Despite some advances in the molecular understanding of UBC, this knowledge still has not been translated to the clinic in terms of improvements in the prognosis and... Read more
    J Cancer Metastasis Treat 2016;2:51-8. | doi:10.4103/2394-4722.171279
    Published on: 29 Feb 2016  | Viewed:2030  | Downloaded:388
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  • Review|Open Access

    Molecular and cellular aspects of extramedullary manifestations of acute myeloid leukemia

    Javad Mohammadiasl , Abbas Khosravi , Mohammad Shahjahani , Shirin Azizidoost , Najmaldin Saki
    The myeloid extramedullary tumor is a solid tumor formed by infiltration of immature myeloid cells in various tissues of the body. This tumor is also identified as chloroma or myeloid sarcoma (MS). MS is a manifestation of acute myeloid leukemia (AML) occurring at presentation or during treatment... Read more
    J Cancer Metastasis Treat 2016;2:44-50. | doi:10.4103/2394-4722.167230
    Published on: 29 Feb 2016  | Viewed:5362  | Downloaded:220
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  • Review|Open Access

    The farnesoid X receptor and colon cancer

    Guofeng Xie , Jean-Pierre Raufman
    Worldwide, colorectal cancer (CRC) is a leading cause of cancer death, primarily because of limited therapeutic options for those with advanced disease. The farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily of ligand-activated transcription factors. Besides its prominent... Read more
    J Cancer Metastasis Treat 2016;2:24-8. | doi:10.4103/2394-4722.164288
    Published on: 15 Jan 2016  | Viewed:801  | Downloaded:172
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  • Review|Open Access

    Roles of dysregulated Notch pathway and small DNA tumor viruses in cancer initiation and progression

    Anthony G. Clementz , Paola Rizzo , Fernanda Martini , Mauro Tognon
    Notch pathway is a major determinant of cell fate, and research within the last 30 years has shown dysfunctions within this pathway in the majority of solid tumors and leukemias. The molecular mechanisms causing aberrant expression of Notch in cancer are still partially known. Mesotheliomas,... Read more
    J Cancer Metastasis Treat 2016;2:11-23. | doi:10.4103/2394-4722.171982
    Published on: 15 Jan 2016  | Viewed:1885  | Downloaded:150
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  • Review|Open Access

    Long non-coding RNAs as key regulators of cancer metastasis

    Pratirodh Koirala , De-Hong Zou , Yin-Yuan Mo
    The recent advances in functional genomics have discovered that a large number of long non-coding RNAs (lncRNAs) are pervasively transcribed from the human genome. Increasing evidence further indicates that lncRNAs are important for gene expression during cell differentiation and development... Read more
    J Cancer Metastasis Treat 2016;2:1-10. | doi:10.4103/2394-4722.171829
    Published on: 15 Jan 2016  | Viewed:198161  | Downloaded:630
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  • Original Article|Open Access

    Withaferin A targeting both cancer stem cells and metastatic cancer stem cells in the UP-LN1 carcinoma cell model

    Lai-Lei Ting , Andy Shau-Bin Chou , Chin-Hsuan Hsieh , Shih-Chieh Hsiung , See-Tong Pang , Shuen-Kuei Liao
    Aim: As our understanding of cancer stem cell (CSC) biology improves, search for inhibitory agents of CSCs and metastatic CSCs (mCSCs) positive for CXCR4 is warranted. Withaferin A (WA), a withanolide extracted from the medicinal plant Withania somnifera, has been shown to exhibit anti-cancer... Read more
    J Cancer Metastasis Treat 2016;2:29-40. | doi:10.4103/2394-4722.172008
    Published on: 15 Jan 2016  | Viewed:3101  | Downloaded:186
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  • Case Report|Open Access

    Hepatocellular carcinoma presenting as rapidly growing sternal mass: an unusual presentation

    Rahul S. Kulkarni , Asha S. Anand , Apurva A. Patel , Sandip A. Shah
    Hepatocellular carcinoma (HCC) is the most common malignant tumor of the liver. The most frequent sites of metastases are lungs, regional lymph nodes, adrenals and bones. However, an isolated sternal metastasis from HCC as an initial presentation has been rarely reported. A 45-year-old man... Read more
    J Cancer Metastasis Treat 2016;2:41-3. | doi:10.4103/2394-4722.169643
    Published on: 15 Jan 2016  | Viewed:9289  | Downloaded:104
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  • Topic: Reviews of Recent Advances in Research and Treatment for Gastroenterological Malignancies|Open Access

    Epithelial-mesenchymal transition in gastroenterological cancer

    Hirohisa Okabe , Kosuke Mima , Seiya Saito , Hiromitsu Hayashi , Katsunori Imai , Hidetoshi Nitta , Daisuke Hashimoto , Akira Chikamoto , Takatoshi Ishiko , Toru Beppu , Hideo Baba
    Epithelial-mesenchymal transition (EMT) was first reported as an essential process in embryonic cells and later showed that cancer cells, regardless of the context, exhibited a similar phenomenon that was crucial for tumor progression. Epithelial cells lose their adhesive characteristic capacity... Read more
    J Cancer Metastasis Treat 2015;1:183-9. | doi:10.4103/2394-4722.165118
    Published on: 15 Oct 2015  | Viewed:2521  | Downloaded:163
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  • Topic: Reviews of Recent Advances in Research and Treatment for Gastroenterological Malignancies|Open Access

    Cancer metabolism in gastrointestinal cancer

    Hiroshi Sawayama , Nobutomo Miyanari , Hideo Baba
    Cancer cells exhibit altered glucose metabolism, mitochondrial dysfunction, anaerobic glycolysis and upregulation of the pentose phosphate pathway (PPP). Recent genetic and metabolic analyses have provided insights into the molecular mechanisms of genes that are involved in the alteration of... Read more
    J Cancer Metastasis Treat 2015;1:172-82. | doi:10.4103/2394-4722.165533
    Published on: 15 Oct 2015  | Viewed:3194  | Downloaded:179
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  • Topic: Reviews of Recent Advances in Research and Treatment for Gastroenterological Malignancies|Open Access

    Trends in clinical use of targeted therapy for gastrointestinal cancers

    Kojiro Eto , Masayuki Watanabe
    Targeted drugs therapies that block the molecular pathways involved in the development and progression of gastro-intestinal (GI) cancers have recently gained considerable attention. In addition to agents targeting vascular endothelial growth factor (VEGF), epidermal growth factor receptor, the... Read more
    J Cancer Metastasis Treat 2015;1:163-71. | doi:10.4103/2394-4722.166997
    Published on: 15 Oct 2015  | Viewed:3255  | Downloaded:133
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  • Topic: Reviews of Recent Advances in Research and Treatment for Gastroenterological Malignancies|Open Access

    Molecular insights into colorectal cancer stem cell regulation by environmental factors

    Daisuke Izumi , Takatsugu Ishimoto , Yasuo Sakamoto , Yuji Miyamoto , Hideo Baba
    Colorectal cancer remains a significant cause of cancer-related mortality worldwide, mainly because of tumor relapse and metastases. Cancer stem cells (CSCs) are considered to be the main cause of resistance to chemotherapeutic agents, as well as being responsible for distant metastases. Although... Read more
    J Cancer Metastasis Treat 2015;1:156-62. | doi:10.4103/2394-4722.165532
    Published on: 15 Oct 2015  | Viewed:4042  | Downloaded:211
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  • Topic: Reviews of Recent Advances in Research and Treatment for Gastroenterological Malignancies|Open Access

    MicroRNAs in gastrointestinal cancer: a novel biomarker and its clinical application

    Yukiharu Hiyoshi , Masayuki Watanabe
    Gastrointestinal (GI) cancers remain one of the most common malignancies and are the major cause of cancer deaths worldwide. Significant advancements have improved our understanding of the pathogenesis and pathology of GI cancers, but high mortality rates, an unfavorable prognosis, and lack of... Read more
    J Cancer Metastasis Treat 2015;1:144-55. | doi:10.4103/2394-4722.161617
    Published on: 15 Oct 2015  | Viewed:2664  | Downloaded:152
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  • Topic: Reviews of Recent Advances in Research and Treatment for Gastroenterological Malignancies|Open Access

    Chronic inflammation and gastrointestinal cancer

    Satoshi Ida , Masayuki Watanabe , Hideo Baba
    Chronic inflammation has been identified as an important risk factor in the development of the gastrointestinal (GI) tract cancers, and the underlying molecular mechanisms have been studied extensively. Chronic inflammation is able to trigger cellular events to promote malignant transformation of... Read more
    J Cancer Metastasis Treat 2015;1:138-43. | doi:10.4103/2394-4722.166994
    Published on: 15 Oct 2015  | Viewed:3961  | Downloaded:220
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  • Topic: Reviews of Recent Advances in Research and Treatment for Gastroenterological Malignancies|Open Access

    The clinical significance of circulating tumor cells in gastrointestinal cancer

    Masaaki Iwatsuki , Junji Kurashige , Takatsugu Ishimoto , Keisuke Kosumi , Yoshifumi Baba , Yasuo Sakamoto , Yuji Miyamoto , Naoya Yoshida , Masayuki Watanabe , Hideo Baba
    Circulating tumor cells (CTCs) are originated from the primary tumor lesion into the blood stream. CTCs could lead to recurrence of gastrointestinal (GI) cancers, even after a curative resection and colonizing in the distant organs to facilitate tumor distant metastasis; however, it has been... Read more
    J Cancer Metastasis Treat 2015;1:130-7. | doi:10.4103/2394-4722.165534
    Published on: 15 Oct 2015  | Viewed:3453  | Downloaded:237
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  • Topic: Reviews of Recent Advances in Research and Treatment for Gastroenterological Malignancies|Open Access

    Overview of genetic and epigenetic alterations in the pathogenesis of esophagogastric junctional adenocarcinoma and esophageal adenocarcinoma: recent findings by next generation sequencing

    Yu Imamura , Ryuma Tokunaga , Kenichi Nakamura , Hideo Baba , Masayuki Watanabe
    Esophagogastric junctional adenocarcinoma is commonly treated as esophageal adenocarcinoma (EAC) and has dramatically increased in Western countries for several decades. The similar trend has been observed in Asian countries (not in China). Barrett’s esophagus (BE) is a widely accepted precursor... Read more
    J Cancer Metastasis Treat 2015;1:123-9. | doi:10.4103/2394-4722.161620
    Published on: 15 Oct 2015  | Viewed:2387  | Downloaded:150
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  • Topic: Reviews of Recent Advances in Research and Treatment for Gastroenterological Malignancies|Open Access

    Epigenetic changes in gastrointestinal cancers

    Hironobu Shigaki , Yoshifumi Baba , Kazuto Harada , Naoya Yoshida , Masayuki Watanabe , Hideo Baba
    Epigenetic alterations, including DNA methylation, histone modifi cation, loss of genome imprinting, chromatin remodeling and non-coding RNAs, are associated with human carcinogenesis. Among them, DNA methylation is a fundamental epigenetic process to modulate gene expression. In cancer cells,... Read more
    J Cancer Metastasis Treat 2015;1:113-22. | doi:10.4103/2394-4722.166991
    Published on: 15 Oct 2015  | Viewed:4798  | Downloaded:181
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  • Topic: Reviews of Recent Advances in Research and Treatment for Gastroenterological Malignancies|Open Access

    Introduction to Volume 1 Issue 3 of Journal of Cancer Metastasis and Treatment

    Masayuki Watanabe
    J Cancer Metastasis Treat 2015;1:111-2. | doi:10.4103/2394-4722.166973
    Published on: 15 Oct 2015  | Viewed:2368  | Downloaded:94
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  • Review|Open Access

    Growth factor receptors: promising drug targets in cancer

    Snigdha Tiash , Ezharul Hoque Chowdhury
    Genetic, epigenetic and somatic changes deregulate the expression of growth factor receptors (GFRs), leading to cancer initiation and progression. Tumor cell growth and survival are orchestrated by clonal expansion and evasion of apoptotic signals in cancer cells. The growth of cells is further... Read more
    J Cancer Metastasis Treat 2015;1:190-200. | doi:10.4103/2394-4722.163151
    Published on: 15 Oct 2015  | Viewed:5101  | Downloaded:261
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  • Original Article|Open Access

    Ten years of lung cancer in a single center: gender, histology, stage and survival

    Regina Gironés , Pedro López , Rebeca Chulvi , Mamen Cañabate , Torregrosa M. Dolores
    Aim: The aim was to describe, in a prospective manner, the clinical, histopathological and epidemiological characteristics of lung cancer patients who attended as outpatients at the Lluís Alcanyís, Xàtiva Medical Oncology Hospital, València, Spain from January 2004 to July 2014. We also analyzed... Read more
    J Cancer Metastasis Treat 2015;1:201-7. | doi:10.4103/2394-4722.166971
    Published on: 15 Oct 2015  | Viewed:2288  | Downloaded:106
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  • Case Report|Open Access

    Is pregnancy wise after 12-year chemotherapy of chronic myeloid leukemia woman?

    Umesh Das , Gurulingaiah Venkata Giri , Kuntejowdahalli Lakshmaiah , Suresh Tagarapura , Lokanatha Dasappa , Govind Babu , Linu Abraham Jacob , Suresh Babu
    Diagnosis of leukemia during pregnancy is a dramatic event that poses challenges to the pregnant woman, the family, and physicians. Chronic myeloid leukemia (CML) comprises up to 10% of pregnancy-associated leukemia. There is no specific guideline for CML management in pregnant women. This study... Read more
    J Cancer Metastasis Treat 2015;1:208-10. | doi:10.4103/2394-4722.158433
    Published on: 15 Oct 2015  | Viewed:1670  | Downloaded:177
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  • Original Article|Open Access

    Withania somnifera extract reduces the invasiveness of MDA-MB-231 breast cancer and inhibits cytokines associated with metastasis

    Kamel F. Khazal , Donald L. Hill
    Aim: The aim was to examine the anti-proliferative effect of a Withania somnifera (WS) root extract in cell cultures and nude mouse xenografts of breast cancer cell line MDA-MB-231. Methods: WS root extract was used to treat tumor cells at concentrations up to 100 μg and for nude mouse... Read more
    J Cancer Metastasis Treat 2015;1:94-100. | doi:10.4103/2394-4722.157601
    Published on: 15 Jul 2015  | Viewed:6713  | Downloaded:167
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  • Original Article|Open Access

    Squamous cell carcinoma of the lung: clinical criteria for treatment strategy

    Agnese Savini , Rossana Berardi , Paola Mazzanti , Miriam Caramanti , Matteo Santoni , Mariagrazia De Lisa , Francesca Morgese , Silvia Rinaldi , Mariangela Torniai , Ilaria Fiordoliva , Azzurra Onofri , Stefano Cascinu
    Aim: Primary lung cancer is the leading cause of human cancer deaths worldwide, and squamous cell carcinoma (SCC) is one of the most frequent histologic subtypes. The aim of our study was to analyze clinical factors potentially affecting the overall outcome of advanced lung SCC patients. Methods:... Read more
    J Cancer Metastasis Treat 2015;1:90-3. | doi:10.4103/2394-4722.157974
    Published on: 15 Jul 2015  | Viewed:5249  | Downloaded:120
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  • Original Article|Open Access

    Prognostic significance of transcription factors FOXA1 and GATA-3 in ductal carcinoma in situ in terms of recurrence and estrogen receptor status

    Mamatha Chivukula , Jennifer Picarsic , Gautam Bulusu , Adam Brufsky , Gretchen Ahrendt , Gloria Carter
    Aim: The aim was to analyze the expression of novel biological transcription markers, forkhead-box A1 (FOXA1), GATA binding protein 3 (GATA-3), and established markers such as Ki-67 (MIB-1) and human epidermal growth factor receptor 2 (HER2) in estrogen receptor (ER(+)) and ER(-) ductal carcinoma... Read more
    J Cancer Metastasis Treat 2015;1:84-9. | doi:10.4103/2394-4722.157600
    Published on: 15 Jul 2015  | Viewed:5093  | Downloaded:100
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  • Case Report|Open Access

    Spinal intradural mature teratoma in an elderly patient

    Atef Ben Nsir , Karim Ben Hammouda , Imed Ben Said , Alia Zhani Kassar , Nidhameddine Kchir , Hafedh Jemel
    Spinal intradural mature teratomas are rarely encountered in adults. In this report, one of the oldest patients ever reported to harbor an intradural mature teratoma of the conus medullaris is presented, and the relevant literature concerning the teratoma’s origin, clinical presentation,... Read more
    J Cancer Metastasis Treat 2015;1:106-10. | doi:10.4103/2394-4722.157808
    Published on: 15 Jul 2015  | Viewed:4587  | Downloaded:117
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  • Review|Open Access

    Urothelial bladder cancer progression: lessons learned from the bench

    Julieta P. Afonso , Rui Freitas , Francisco Lobo , António Morais , Jorge Oliveira , Teresina Amaro , Rui M. Reis , Fátima M. Baltazar , Adhemar Longatto-Filho , Lúcio L. Santos
    Urothelial bladder carcinoma (UBC) is an intricate malignancy with a variable natural history and clinical behavior. Despite developments in diagnosis/prognosis refi nement and treatment modalities, the recurrence rate is high, and progression from non-muscle to muscle invasive UBC commonly leads... Read more
    J Cancer Metastasis Treat 2015;1:57-66. | doi:10.4103/2394-4722.157377
    Published on: 15 Jul 2015  | Viewed:6543  | Downloaded:160
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  • Original Article|Open Access

    Non-anthracycline chemotherapy associated with a poor outcome in elderly Egyptian patients with diffuse large B-cell non-Hodgkin lymphoma

    Ahmed A. Zeeneldin , Yasser A. Sallam , Ayman A. Gaber , Amgad A. Shaheen
    Aim: Rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) is the standard treatment for patients with diffuse large B-cell non-Hodgkin lymphoma (DLBCNHL). Nevertheless, anthracyclines are contraindicated for some patients, e.g. cardiac dysfunction, severe hepatic... Read more
    J Cancer Metastasis Treat 2015;1:76-83. | doi:10.4103/2394-4722.156767
    Published on: 15 Jul 2015  | Viewed:4780  | Downloaded:116
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  • Case Report|Open Access

    Orbital metastasis from anorectal carcinoma

    Pavan Kumar Lachi , Megha S. Uppin , Monica Irukulla , Kotiyala V. Jaganadha Rao Naidu
    Pulmonary and liver metastases are common sites of distant metastasis from the rectal carcinoma. Metastases to the head and neck region are uncommon from carcinoma of the rectum, and orbital metastases are extremely rare. Here, we describe a 27-year-old female, who was diagnosed as a case of... Read more
    J Cancer Metastasis Treat 2015;1:104-5. | doi:10.4103/2394-4722.158434
    Published on: 15 Jul 2015  | Viewed:3797  | Downloaded:94
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  • Editorial|Open Access

    Introduction to Volume 1 Issue 2 of Journal of Cancer Metastasis and Treatment

    Lucio Miele
    J Cancer Metastasis Treat 2015;1:43. | doi:10.4103/2394-4722.160150
    Published on: 15 Jul 2015  | Viewed:2010  | Downloaded:87
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  • Review|Open Access

    Role of circulating tumor cells in future diagnosis and therapy of cancer

    Pravin D. Potdar , Navjeet Kaur Lotey
    Circulating tumor cells (CTCs) have become a blistering topic of discussion for oncologists because of their tremendous potential in the diagnosis and treatment of cancer. Over the past few years, they have been doled with quite an amount of research in this area understanding that CTCs are shed... Read more
    J Cancer Metastasis Treat 2015;1:44-56. | doi:10.4103/2394-4722.158803
    Published on: 15 Jul 2015  | Viewed:19127  | Downloaded:841
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  • Original Article|Open Access

    Detection and quantification of extracellular microRNAs in medulloblastoma

    Tarek Shalaby , Giulio Fiaschetti , Sylvain Baulande , Nicolas U. Gerber , Martin Baumgartner , Michael A. Grotzer
    Aim: Medu lloblastoma (MB) is the most common malignant brain tumor in children. The crucial role of extracellular-microRNAs (ex-miRNAs) in cancer has been widely recognized; however, their role in MB remains unknown. This study aimed to investigate MB-driven ex-miRNAs. Methods: Microarray... Read more
    J Cancer Metastasis Treat 2015;1:67-75. | doi:10.4103/2394-4722.157068
    Published on: 15 Jul 2015  | Viewed:3966  | Downloaded:109
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  • Case Report|Open Access

    Metastatic inguinal lymph nodes with two different histological types in a case of carcinoma of unknown primary site

    Mukur Dipi Ray , Shivam Vatsal , Sunil Kumar
    Cancer of unknown primary site is a group of uncommon cancers where patients present with metastatic disease and the primary site is not identified, even after a complete workup to establish the diagnosis. Inguinal metastasis with unknown primary is even more uncommon, and histological type is... Read more
    J Cancer Metastasis Treat 2015;1:101-3. | doi:10.4103/2394-4722.157178
    Published on: 15 Jul 2015  | Viewed:11444  | Downloaded:435
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  • Case Report|Open Access

    Metachronous metastasis of renal cell carcinoma to bilateral testis

    Sameer Nain , Suman Kharkwal , Onkar Kaur
    Unusual site metastasis as a presenting complaint of renal cell carcinoma (RCC) has been reported previously in the literature. RCC is a tumor with notoriously unpredictable behavior. The authors report an unusual case of metachronous bilateral testicular metastasis in a patient who operated for... Read more
    J Cancer Metastasis Treat 2015;1:39-40. | doi:10.4103/2394-4722.153913
    Published on: 15 Apr 2015  | Viewed:1338  | Downloaded:70
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  • Original Article|Open Access

    Incidence of bone metastasis in squamous cell carcinoma of the buccal mucosa

    Virendra Bhandari
    Aim: This retrospective study was performed to show the incidence of bone metastasis from carcinoma of the buccal mucosa. Head and neck cancer is a leading health problem in India due to an increased incidence of tobacco use and poor oral hygiene. Squamous cell carcinoma of the buccal mucosa is... Read more
    J Cancer Metastasis Treat 2015;1:27-30. | doi:10.4103/2394-4722.153444
    Published on: 15 Apr 2015  | Viewed:6447  | Downloaded:379
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  • Case Report|Open Access

    Complete response with fotemustine and bevacizumab after early progression following radiotherapy and temozolomide treatment in patient with glioblastoma multiforme

    Ovidio Fernández Calvo , María Eva Pérez López , Jesús García Gómez
    Glioblastoma multiforme is the most common type of primary central nervous system tumor and is noted for its short survival and poor response to chemotherapeutic agents. Unfortunately, the relapse rate is very high, and there is no reference drug for second-line treatment. In this study, a... Read more
    J Cancer Metastasis Treat 2015;1:36-8. | doi:10.4103/2394-4722.153446
    Published on: 15 Apr 2015  | Viewed:2065  | Downloaded:109
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  • Review|Open Access

    Patient-derived xenograft models for oncology drug discovery

    Gang Li
    The success of targeted therapies for cancer patients rests on three major components: the right target(s), the right drug and drug combination, and the right patient population. Although much progress has been made in understanding the mechanism of disease and in refi ning pharmaceutical... Read more
    J Cancer Metastasis Treat 2015;1:8-15. | doi:10.4103/2394-4722.152769
    Published on: 15 Apr 2015  | Viewed:3920  | Downloaded:504
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  • Original Article|Open Access

    Changes in human epidermal growth factor receptor 2 status between primary breast/gastric carcinomas and synchronous metastatic lymph nodes: how can we explain them?

    Antonio Ieni , Valeria Barresi , Giovanni Branca , Luana Licata , Rosario Alberto Caruso , Giovanni Tuccari
    Aim: Previous studies demonstrated discordant expression of human epidermal growth-factor receptor 2 ( HER2) between primary cancer and their recurrence/metastasis. This study further evaluated HER2 status between primary gastric and breast invasive carcinomas and paired metastatic disease to... Read more
    J Cancer Metastasis Treat 2015;1:21-6. | doi:10.4103/2394-4722.153445
    Published on: 15 Apr 2015  | Viewed:2863  | Downloaded:125
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  • Case Report|Open Access

    Malignant ascites with omental metastasis: a rare event in prostate cancer

    Rajeev Saini , Chandragouda Dodagoudar , Vineet Talwar , Sajjan Singh
    Prostate cancer is the most common type of male malignancy in the world and approximately 10-20% of prostate cancer shows a metastatic disease at initial diagnosis commonly to the bones, vertebrae, ribs, long bones, and skull. However, prostate cancer metastasis to the omentum with malignant... Read more
    J Cancer Metastasis Treat 2015;1:34-5. | doi:10.4103/2394-4722.152767
    Published on: 15 Apr 2015  | Viewed:3179  | Downloaded:226
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  • Review|Open Access

    Risk factors and molecular mechanisms of esophageal cancer: differences between the histologic subtypes

    Masayuki Watanabe
    The two major histologic subtypes of esophageal cancer have different risk factors as well as different molecular mechanisms. In this review, the differences in risk factors and genetic/epigenetic alterations between esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC)... Read more
    J Cancer Metastasis Treat 2015;1:1-7. | doi:10.4103/2394-4722.153534
    Published on: 15 Apr 2015  | Viewed:11326  | Downloaded:289
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  • Original Article|Open Access

    Association between the cytotoxic T-lymphocyte antigen-4 polymorphisms and breast cancer risk and prognosis

    Meraj Farbod , Seyed Mostafa Shiryazdi , Hamid Harazi , Tahereh Nazari , Mohammad Hasan Sheikhha
    Aim: The aim was to evaluate the potential influences of cytotoxic T-lymphocyte antigen-4 (CTLA-4) gene polymorphisms on breast cancer risk, the distribution of CTLA-4 single nucleotide polymorphisms (1661AG) in breast cancer patients and control subjects was investigated. Methods: In this... Read more
    J Cancer Metastasis Treat 2015;1:16-20. | doi:10.4103/2394-4722.153314
    Published on: 15 Apr 2015  | Viewed:4100  | Downloaded:112
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  • Case Report|Open Access

    Early stage squamous cell carcinoma of the tonsil presenting with multiple organ metastases including skin and brain after successful local treatment

    Susovan Banerjee , Dipankar Kundu , Mukti Mukherjee , Pradip Kumar Maiti
    Early stage carcinoma of the tonsil is curable, and the incidence of systemic metastasis is very low and central nervous system involvement is very rare. A patient diagnosed with early stage tonsillar carcinoma treated with chemoradiation was followed by brachytherapy boost. One and half years... Read more
    J Cancer Metastasis Treat 2015;1:31-3. | doi:10.4103/2394-4722.152761
    Published on: 15 Apr 2015  | Viewed:4333  | Downloaded:452
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  • Letter to Editor|Open Access

    Cancer preventing spices

    Ishtiaque Alam , Hashmat Imam , Zarnigar Riaz
    J Cancer Metastasis Treat 2015;1:41-2. | doi:10.4103/2394-4722.154131
    Published on: 15 Apr 2015  | Viewed:1244  | Downloaded:103
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Journal of Cancer Metastasis and Treatment Print ISSN: 2394-4722; Online ISSN: 2454-2857
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