• Original Article|Open Access

    The synergy of Helicobacter pylori and lipid metabolic disorders in induction of Th17-related cytokines in human gastric cancer

    Jie Liu , Han Wang , Gang Chen , Mo Yang , Zhi-Xian Wu , Russell Erick Ericksen , Alice Sze Tsai Wong , Weiping Han , Jin-Zhang Zeng
    Aim: To study the impact of Helicobacter pylori (H. pylori) and lipid metabolic disorder on the expression of Th17-related cytokines in gastric cancer (GC). Methods: GC specimens were randomly collected from 42 patients, of whom 15 had H. pylori infection and 27 were without. Tumor RNA was extracted for reverse transcription quantitative polymerase chain reaction quantification of gene expression. Results: The mRNA levels of interleukin (IL)-6 and leptin, which are known to regulate Th17 differentiation, were upregulated by 20 and 6 folds, respectively, in H. pylori-infected compared to... Read more
    J Cancer Metastasis Treat 2017;3:169-76. | doi:10.20517/2394-4722.2017.46
    Published on: 29 Aug 2017  | Viewed:360  | Downloaded:40
  • Original Article|Open Access

    Papaya black seeds have beneficial anticancer effects on PC-3 prostate cancer cells

    Khalid S. Alotaibi , Haiwen Li , Reza Rafi , Rafat A. Siddiqui
    Aim: The study investigated the effect of papaya seeds on prostate cancer (PC) using PC-3 cell line because papaya seeds have effects on the male reproductive system notably decreasing sperm concentration, motility, and viability, leading to azoospermia after short-to-long-term treatment. Methods: The black seeds from yellow (ripe) papaya and white seeds from green (unripe) papaya were harvested and then extracted in water, 80% methanol, and hexane. The cytotoxic effects of seeds extracts were determined using a WST-1 proliferation assay. The amount of total polyphenols was determined using... Read more
    J Cancer Metastasis Treat 2017;3:161-8. | doi:10.20517/2394-4722.2017.33
    Published on: 28 Aug 2017  | Viewed:533  | Downloaded:42
  • Original Article|Open Access

    TGF-β stimulation of EMT programs elicits non-genomic ER-α activity and anti-estrogen resistance in breast cancer cells

    Maozhen Tian , William P. Schiemann
    Aim: Estrogen receptor-α (ER-α) activation drives the progression of luminal breast cancers. Signaling by transforming growth factor-β (TGF-β) typically opposes the actions of ER-α; it also induces epithelial-mesenchymal transition (EMT) programs that promote breast cancer dissemination, stemness and chemoresistance. The impact of EMT programs on nongenomic ER-α signaling remains unknown and was studied herein. Methods: MCF-7 and BT474 cells were stimulated with TGF-β to induce EMT programs, at which point ER-α expression, localization, and nongenomic interactions with receptor tyrosine... Read more
    J Cancer Metastasis Treat 2017;3:150-60. | doi:10.20517/2394-4722.2017.38
    Published on: 21 Aug 2017  | Viewed:682  | Downloaded:54
  • Case Report|Open Access

    Uterine large cell neuroendocrine carcinoma with unusual colonic metastasis

    Antonio Ieni , Giuseppe Angelico , Rosalba De Sarro , Francesco Fleres , Antonio Macrì , Giovanni Tuccari
    A 78-year-old female patient arrived at our practice complaining of progressive abdominal increase and presenting a clinical picture of intestinal obstruction. At physical examination, the abdomen appeared distended, moderately painful with the presence of a mass of hard consistency. Abdominal computed tomography scan showed a large hypodense pelvic mass that indicated a compression and lateral deviation of the uterus and bladder. Microscopically, the mass showed a uniform solid pattern, composed of medium and large-sized cells with hyperchromatic and pleomorphic nuclei demonstrating high... Read more
    J Cancer Metastasis Treat 2017;3:144-9. | doi:10.20517/2394-4722.2017.15
    Published on: 16 Aug 2017  | Viewed:382  | Downloaded:36
  • Case Report|Open Access

    Large chest wall fibromatosis with challenging treatment plan

    Rashi Agrawal , Prekshi Choudhary , Arun Kumar Goel , Vaishali Zamre , Sandeep Agarwal , Dinesh Singh
    The primary mode of treatment for desmoid tumors is surgical excision. However, high recurrence rates (39-79%) have been reported when surgery is used alone. The role of adjuvant radiotherapy after surgical resection of primary disease is controversial and should be based on a balanced discussion of potential morbidity from radiotherapy and local recurrence. In this patient, the maximum dimension of tumor was 21 cm. This is a larger chest wall fibromatosis than has been reported thus far, to the best of our knowledge. In this case, post-operative margins were free, but in view of the large... Read more
    J Cancer Metastasis Treat 2017;3:139-43. | doi:10.20517/2394-4722.2017.02
    Published on: 21 Jul 2017  | Viewed:471  | Downloaded:59
  • Review|Open Access

    Role of adenosine in tumor progression: focus on A2B receptor as potential therapeutic target

    Claudia Sorrentino , Silvana Morello
    Adenosine receptors are a family of G-coupled receptors which mediate the anti-inflammatory and immune-suppressive effects of adenosine in a damaged tissue. A large number of evidence indicate that the accumulation of adenosine under hypoxic conditions favors tumor progression, helping cancer cells to evade immune responses. Tumor cells and/or lymphoid and myeloid cells can express the adenosine-generating enzyme CD73 and/or A2A receptor, which in turn strongly suppresses an effective T-cell-mediated response, while promotes the activity of suppressive cells such as Treg and myeloid-derived... Read more
    J Cancer Metastasis Treat 2017;3:127-38. | doi:10.20517/2394-4722.2017.29
    Published on: 17 Jul 2017  | Viewed:1269  | Downloaded:135
  • Topic: Cancer Immunotherapy|Open Access

    Systemic humoral responses of non-muscle-invasive bladder cancer during BCG treatment: less is more

    Fernando M. Calais da Silva , Paula A. Videira , Dário Ligeiro , Maria Guadalupe Cabral , Richard Sylvester , Fernando E. Calais da Silva , Hélder Trindade
    Aim: Intravesical Bacille Calmette-Guérin (BCG) is the mainstay adjuvant treatment of non-muscle-invasive bladder cancer. However, one third of the patients on BCG regimen relapse within the first year of treatment. This study aimed at identifying biomarkers to predict response to BCG treatment. Methods: Gene expression was analyzed in blood cells of 58 patients treated with BCG through six consecutive weekly instillations and then at month 3, 6, 9, and 12. Cytokines tumor necrosis factor (TNF)-α, interleukin (IL)-10, interferon (IFN)-γ, IL-1β, IL-2, IL-4, and IL-6; chemokines CCL2, CCL3,... Read more
    J Cancer Metastasis Treat 2017;3:116-26. | doi:10.20517/2394-4722.2017.25
    Published on: 14 Jul 2017  | Viewed:733  | Downloaded:37
  • Case Report|Open Access

    Report of primary leiomyosarcoma of renal pelvis and literature review

    Abhidha Malik , Ritesh Kumar , Abhishek Shankar , Sunil Chumber , Sameer Bakhshi , Seema Kaushal , Bala Thirunavukkarasu
    Primary sarcomas of kidney are exceptionally rare tumors, accounting for only 1-2% of all malignant tumors of kidney. Leiomyosarcoma (LMS) is the most common histological subtype among all renal sarcomas. The authors describe here a case of primary leiomyosarcoma of renal pelvis in a 50-year-old lady, presenting with flank pain. Based on triple phase cardio-electroencephalographic covariance tracing abdomen, presumptive diagnosis of renal cell carcinoma/renal sarcoma/neurogenic tumor was made and patient underwent radical nephrectomy. Microscopy reflected spindle cell tumor which showed... Read more
    J Cancer Metastasis Treat 2017;3:111-5. | doi:10.20517/2394-4722.2017.12
    Published on: 30 Jun 2017  | Viewed:354  | Downloaded:28
  • Short Communication|Open Access

    Management of choroidal metastasis using external beam radiotherapy: a retrospective study and review of the literature

    Zakaria Ahmed Youbi , Enachescu Ciprian , Caraivan Ionela , Bennani Zineb , Khounigere Majdouline , Kotzki Léa , Pialat Pierre-Marie , Sesques Pierre , Yossi Séna
    Aim: Choroidal metastases are rare in the evolution of solid cancers and constitute exceptional metastatic sites involving functional visual prognosis. The authors conducted a retrospective study to determine the interest of external radiotherapy for the treatment of choroidal metastases. Methods: The authors reviewed the records of 28 patients with choroidal metastases who had breast (n = 15), lung (n = 9), ovarian (n = 1), kidney (n = 1), prostate (n = 1) cancer or carcinoma with unknown primitive at the moment of the diagnosis (n = 1). The median age was 58 years (extremes: 34-71 years).... Read more
    J Cancer Metastasis Treat 2017;3:105-10. | doi:10.20517/2394-4722.2017.07
    Published on: 30 Jun 2017  | Viewed:441  | Downloaded:61
  • Original Article|Open Access

    Impact of health care insurance on overall survival of patients with multiple myeloma and monoclonal gammopathy of undetermined significance

    Srinivas S. Devarakonda , Runhua Shi , Ellen Friday , Reinhold Munker , Jonathan Glass , Francesco Turturro
    Aim: Health care insurance improves access to care and thus outcome in patients with solid tumors. Little information on the impact of health care insurance on hematological malignancies including multiple myeloma exists. The authors aimed to analyze the effect of health care insurance on the survival of patients with multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS) at Louisiana State University Health Sciences Center in Shreveport, LA. Methods: Two hundred fifty seven patients were reviewed, of which 208 had MM and 49 had MGUS. Results: One hundred and... Read more
    J Cancer Metastasis Treat 2017;3:100-4. | doi:10.20517/2394-4722.2017.19
    Published on: 9 Jun 2017  | Viewed:900  | Downloaded:58
  • Original Article|Open Access

    Combination of insulin-like growth factor-1, IGF binding protein-3, chromogranin A and prostate specific antigen can improve the detection of prostate cancer

    Saleh Ahmed Kamaleldin Saleh , Heba Mohamed Adly , Anmar Mohammed Nassir
    Aim: Prostate cancer (PCa) is the second most prevalent male cancer worldwide and designated the sixth most frequent male cancer in Arab countries. Although prostate specific antigen (PSA) has become the best and most valuable biomarker for screening of PCa, elevated levels of PSA can reflect the presence of malignant cells but can overlap with benign prostatic diseases. There is a necessity to develop and improve current tools for early detection and diagnosis of PCa. This study was done to evaluate the validation of serum insulin-like growth factor-1 (IGF-1), IGF binding protein-3... Read more
    J Cancer Metastasis Treat 2017;3:82-9. | doi:10.20517/2394-4722.2017.20
    Published on: 24 May 2017  | Viewed:969  | Downloaded:50
  • Original Article|Open Access

    Real-time quantitative PCR array to study drug-induced changes of gene expression in tumor cell lines

    Stefano Amatori , Giuseppe Persico , Mirco Fanelli
    Aim: Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) is still the “gold standard” for quantitative analysis of mRNA and the study of differentially expressed genes. Methods: The authors describe a RT-qPCR array that exploits SYBR Green dye-based detection to perform reliable gene expression analysis on 41 genes involved in several pathways linked to DNA damage response, cell cycle progression, cellular senescence, and programmed cell death. To validate the RT-qPCR array, the authors investigated changes of the gene expression profile of HeLa cells treated with two... Read more
    J Cancer Metastasis Treat 2017;3:90-9. | doi:10.20517/2394-4722.2017.22
    Published on: 24 May 2017  | Viewed:1088  | Downloaded:94
  • Commentary|Open Access

    A new twist to neurotransmitter receptors and cancer

    Hildegard M. Schuller
    J Cancer Metastasis Treat 2017;3:71-7. | doi:10.20517/2394-4722.2017.18
    Published on: 28 Apr 2017  | Viewed:1249  | Downloaded:91
  • Case Report|Open Access

    Chest wall metastasis in squamous cell carcinoma of buccal mucosa

    Jayesh Shyamnandan Singh , Ashutosh Das Sharma
    Metastases from head and neck cancers is rare occurrence. The common form of failure/recurrence in these cancers are local site recurrence or nodal metastases. Distant metastases are very rare and are most commonly seen in the lung, brain, liver and bones, and the latent period between the development of the primary and the distant metastases is usually long. There are very few cases reported of chest wall metastases from squamous cell carcinoma of head and neck. This article reports such a case of squamous cell carcinoma of buccal mucosa metastasizing to the chest wall four months after... Read more
    J Cancer Metastasis Treat 2017;3:78-81. | doi:10.20517/2394-4722.2017.08
    Published on: 28 Apr 2017  | Viewed:518  | Downloaded:57
  • Original Article|Open Access

    Expression of PANDA, LincRNA-p21, PUMA in lung tissues of lung cancer patients in the Xuanwei and non-Xuanwei areas of Yunnan Province

    Kai-Yun Yang , Zhi-Qiang Shen , Yue-Feng He , Kushal Rizal , Hui Tan , An-Ning Chen , Yun-Chao Huang , Guang-Qiang Zhao , Yu-Jie Lei
    Aim: To study the expression of PANDA, LincRNA-p21, and PUMA in lung tissue of patients with lung cancer from Xuanwei of Yunnan Province. Methods: Forty-five cases of lung cancer patients from Xuanwei and 42 lung cancer cases from non-Xuanwei were enrolled. Extraction of RNA was done using the Trizol kit. Real-time fluorescence quantitative PCR assay was done to obtain the relative expression. Results: Expressions of PANDA, LincRNA-p21, and PUMA in male and female patients or in squamous cell carcinoma and adenocarcinoma were not significantly different (P > 0.05). However, expression of... Read more
    J Cancer Metastasis Treat 2017;3:65-70. | doi:10.20517/2394-4722.2016.65
    Published on: 27 Mar 2017  | Viewed:675  | Downloaded:81
  • Review|Open Access

    DNA damage-induced nuclear factor-kappa B activation and its roles in cancer progression

    Wei Wang , Arul M. Mani , Zhao-Hui Wu
    DNA damage is a vital challenge to cell homeostasis. Cellular responses to DNA damage (DDR) play essential roles in maintaining genomic stability and survival, whose failure could lead to detrimental consequences such as cancer development and aging. Nuclear factor-kappa B (NF-kB) is a family of transcription factors that plays critical roles in cellular stress response. Along with p53, NF-kB modulates transactivation of a large number of genes which participate in various cellular processes involved in DDR. Here the authors summarize the recent progress in understanding DNA damage response... Read more
    J Cancer Metastasis Treat 2017;3:45-59. | doi:10.20517/2394-4722.2017.03
    Published on: 27 Mar 2017  | Viewed:1789  | Downloaded:129
  • Original Article|Open Access

    Percutaneous, computed tomography guided neurolysis using continuous radiofrequency for pain reduction in oncologic patients

    Periklis Zavridis , Maria Tsitskari , Argyro Mazioti , Dimitrios Filippiadis
    Aim: This study evaluates the efficacy and safety of percutaneous computed tomography (CT)-guided neurolysis using continuous radiofrequency for pain reduction in oncologic patients. Methods: Over the course of 16 months, 22 patients underwent radiofrequency neurolysis as palliative therapy for pain reduction in celiac and splachnic plexus (n = 9), thoracic (n = 1), lumbar (n = 2) and superior hypogastric plexus (n = 5), as well as stellate ganglion (n = 5). Pain levels before treatment, one week after treatment, and at the last follow-up (average follow-up 6 months) were compared by means... Read more
    J Cancer Metastasis Treat 2017;3:60-4. | doi:10.20517/2394-4722.2017.04
    Published on: 27 Mar 2017  | Viewed:399  | Downloaded:46
  • Review|Open Access

    Cytogenetic and molecular basis of BCR-ABL myelodysplastic syndrome: diagnosis and prognostic approach

    Mostafa Paridar , Omid Kiani Ghalesardi , Mohammad Seghatoleslami , Ahmad Ahmadzadeh , Abbas Khosravi , Najmaldin Saki
    Myelodysplastic syndromes (MDS) include a heterogeneous group of blood disorders generally afflicting older people. Several genetic factors have been reported from these patients that have an important role in the diagnosis, prognosis, and treatment of this disease. BCR-ABL1 is a genetic factor that has occasionally been reported in some studies. This review attempts to characterize MDS patients reported to harbor this fusion and to assess the diagnostic, therapeutic, and prognostic potential of BCR-ABL1 fusionin MDS patients. This review showed that BCR-ABL fusion has been reported in 22... Read more
    J Cancer Metastasis Treat 2017;3:38-44. | doi:10.20517/2394-4722.2016.61
    Published on: 28 Feb 2017  | Viewed:1050  | Downloaded:121
  • Topic: Circulating Tumor Cells: Diagnostics and Clinical Applications|Open Access

    A versatile method for enumeration and characterization of circulating tumor cells from patients with breast cancer

    Ujjwala M. Warawdekar , Vani Parmar , Aruna Prabhu , Abhay Kulkarni , Meenal Chaudhari , Rajendra A. Badwe
    Aim: To establish a standardized protocol for the isolation and enumeration of circulating tumor cells (CTCs) from peripheral blood of patients with metastatic breast cancer. Methods: The protocol used tumor cells spiked in a lymphoid cell line with detection by flow cytometry and quantitative reverse transcription polymerase chain reaction (QRT-PCR). Cells of the human mammary cancer subtypes were spiked into Jurkat cells, which served as the lymphocyte designate in numbers from 10 to 500 per 105 Jurkat cells. This mixed population was probed for CD45, EpCAM, and pancytokeratin acquired... Read more
    J Cancer Metastasis Treat 2017;3:23-33. | doi:10.20517/2394-4722.2016.66
    Published on: 23 Feb 2017  | Viewed:1598  | Downloaded:112
  • Case Report|Open Access

    Alkaline phosphatase flare with hyperostosis of bone metastases in lung adenocarcinoma treated with gefitinib

    Hiroto Kaneko , Kazuho Shimura , Yosuke Matsumoto , Mihoko Yoshida , Masafumi Taniwaki , Junya Kuroda
    Alkaline phosphatase (ALP) flare has been reported to occur during cancer treatment as a favorable event, particularly in the presence of bone metastasis. There have been only a few reports in lung cancer and associated radiographic findings have seldom been described. The authors observed ALP flare in a female patient with lung adenocarcinoma soon after the initiation of gefitinib. Moreover, on computed tomography, metastatic lesions of the rib and thoracic spine showed marked hyperostosis, with sizes larger than the original bone structure, suggesting efficacy of gefitinib. The... Read more
    J Cancer Metastasis Treat 2017;3:34-7. | doi:10.20517/2394-4722.2016.70
    Published on: 23 Feb 2017  | Viewed:636  | Downloaded:64
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