Latest
  • Case Report|Open Access

    Cryptic NUP214-ABL1 fusion with complex karyotype, episomes and intra-tumor genetic heterogeneity in a T-cell lymphoblastic lymphoma

    Moneeb A.K Othman, Beate Grygalewicz, Agnieszka Kołkowska-Leśniak, Joana B. Melo, Isabel M. Carreira, Thomas Liehr
    T-lymphoblastic lymphoma (T-LBL) is a rare and aggressive form of non-Hodgkin’s lymphoma and little is known about their molecular background. However, complex karyotypes were already related to this group of malignancy and associated with poor outcome. Here, we describe a 17-year-old female being diagnosed with T-LBL and a normal karyotype after standard G-banding with trypsin-Giemsa (GTG)-banding. However, further analyses including high-resolution molecular approaches, array-comparative genomic hybridization (aCGH), multiplex ligation-dependent probe amplification, fluorescence in situ... Read more
    J Cancer Metastasis Treat 2018;4:50. | doi:10.20517/2394-4722.2018.41
    Published on: 21 Sep 2018  | Viewed:0  | Downloaded:0
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  • Review|Open Access

    NSAID celecoxib: a potent mitochondrial pro-oxidant cytotoxic agent sensitizing metastatic cancers and cancer stem cells to chemotherapy

    Stephen John Ralph, Sam Nozuhur, Rafael Moreno-Sánchez, Sara Rodríguez Enríquez, Rhys Pritchard
    Intermittent hypoxia within tumor microenvironments causes pro-oxidative stress impairing oxidative phosphorylation (OxPhos) and increases mitochondrial production of reactive oxygen species (ROS). In primary tumors this provokes metabolic reprogramming of both tumor cells and cancer stem cells and emergence of highly metastatic cancer cells. Tumor reprogramming is initiated by activating nuclear respiratory factors and hypoxia-inducible factors in response to changes in oxygen and ROS levels. Hence, hypoxia-induced pro-oxidative stress drives invasion and metastasis. However, it is also... Read more
    J Cancer Metastasis Treat 2018;4:49. | doi:10.20517/2394-4722.2018.42
    Published on: 20 Sep 2018  | Viewed:14  | Downloaded:1
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  • Editorial|Open Access

    Introduction to the special issue on reviews of gastric cancer metastasis and treatment

    Masayuki Watanabe
    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment
    J Cancer Metastasis Treat 2018;4:48. | doi:10.20517/2394-4722.2018.60
    Published on: 17 Sep 2018  | Viewed:59  | Downloaded:4
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  • Review|Open Access

    Unmasking tumor heterogeneity and clonal evolution by single-cell analysis

    Xiaoshan Shi, Papia Chakraborty, Amitabha Chaudhuri
    The intratumoral heterogeneity orchestrated by the tumor intrinsic and extrinsic mechanisms enable cancers to persist and spread notwithstanding the use of aggressive interventional therapies. The heterogeneity is revealed at multiple levels - at the level of individual tumor cells, in the cellular composition of tumor infiltrates and in the chemical microenvironment in which the cells reside. Deconvoluting the complex nature of the cell types present in the tumor, along with the homo and heterotypic interactions between different cell types can produce novel insights of biological and... Read more
    This article belongs to the Special Issue Intra-Tumour Genetic Heterogeneity
    J Cancer Metastasis Treat 2018;4:47. | doi:10.20517/2394-4722.2018.32
    Published on: 31 Aug 2018  | Viewed:536  | Downloaded:101
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  • Original Article|Open Access

    Increased ARF6 activation correlates with HGF stimulation in non-invasive prostate cancer cells

    Claire Morgan, Lucy J. Swithenbank, Helen Whiteland, Shareen H. Doak
    Aim: The effects of hepatocyte growth factor (HGF) on a non-invasive prostate cancer cell line (CAHPV-10), expressing cMET were studied, to mimic the possible effects neo-adjuvant androgen deprivation therapy may have in promoting tumour progression. Methods: Prostate epithelial cells and prostate cancer cells derived from cancer metastatic sites were analysed using cell culture assays, immunofluorescence, quantitative real-time polymerase chain reaction and western blotting, with or without HGF stimulation. Results: HGF significantly enhanced cell proliferation and induced cell scattering... Read more
    J Cancer Metastasis Treat 2018;4:46. | doi:10.20517/2394-4722.2018.19
    Published on: 30 Aug 2018  | Viewed:260  | Downloaded:90
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  • Editorial|Open Access

    Introduction of the special issue “How does the prostate cancer microenvironment affect the metastatic process and/or treatment outcome?”

    Jason P. Webber, Klaus Pors
    This article belongs to the Special Issue How does the prostate cancer microenvironment affect the metastatic process and/or treatment outcome?
    J Cancer Metastasis Treat 2018;4:45. | doi:10.20517/2394-4722.2018.46
    Published on: 21 Aug 2018  | Viewed:287  | Downloaded:121
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  • Review|Open Access

    Expression and regulation of aldehyde dehydrogenases in prostate cancer

    Ali I. M. Ibrahim, Maria Sadiq, Fiona M. Frame, Norman J. Maitland, Klaus Pors
    The functional role of aldehyde dehydrogenases (ALDHs) in prostate cancer remains an area of some controversy. Many studies have used high ALDH functional activity to isolate putative cancer stem cells with tumour-initiating and propagating properties, while evidence is also emerging about the involvement of specific isoforms in migration, invasiveness and metastasis. Identification of specific ALDH isoforms, which contribute to both drug resistance and aggressiveness of the disease remains a challenge within the complex heterogeneity of prostate cancer. The purpose of this perspective is... Read more
    This article belongs to the Special Issue How does the prostate cancer microenvironment affect the metastatic process and/or treatment outcome?
    J Cancer Metastasis Treat 2018;4:44. | doi:10.20517/2394-4722.2018.07
    Published on: 21 Aug 2018  | Viewed:382  | Downloaded:123
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  • Review|Open Access

    Centrosome aberrations and chromosome instability contribute to tumorigenesis and intra-tumor heterogeneity

    Shirley Jusino, Fabiola M. Fernández-Padín, Harold I. Saavedra
    Centrosomes serve as the major microtubule organizing centers in cells and thereby contribute to cell shape, polarity, and motility. Also, centrosomes ensure equal chromosome segregation during mitosis. Centrosome aberrations arise when the centrosome cycle is deregulated, or as a result of cytokinesis failure. A long-standing postulate is that centrosome aberrations are involved in the initiation and progression of cancer. However, this notion has been a subject of controversy because until recently the relationship has been correlative. Recently, it was shown that numerical or structural... Read more
    This article belongs to the Special Issue Intra-Tumour Genetic Heterogeneity
    J Cancer Metastasis Treat 2018;4:43. | doi:10.20517/2394-4722.2018.24
    Published on: 7 Aug 2018  | Viewed:478  | Downloaded:75
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  • Review|Open Access

    Genomic heterogeneity meets cellular energetics: crosstalk between the mitochondria and the cell cycle

    Erica L. Herrera, Seham Z. Azzam, Madison C. Berger, Laura A. Diaz-Martinez
    Changes in cellular energetics and genomic instability are two characteristics of cancers that have been studied independently. Evidence of cross-talk between mitochondria function and nuclear function has started to emerge, suggesting that these pathways can influence one another. Here we review recent evidence that links the mitochondria and the cell cycle. This evidence indicates bidirectional cross-talk where mitochondria function can regulate the cell cycle and induce genomic instability, and conversely, the cell cycle machinery regulates mitochondria function. Implications for this... Read more
    This article belongs to the Special Issue Intra-Tumour Genetic Heterogeneity
    J Cancer Metastasis Treat 2018;4:42. | doi:10.20517/2394-4722.2018.35
    Published on: 6 Aug 2018  | Viewed:558  | Downloaded:168
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  • Original Article|Open Access

    Extracellular control of chromosomal instability and maintenance of intra-tumoral heterogeneity

    Yi-Hong Zhou, Kambiz Afrasiabi, Mark E. Linskey
    Aim: Current cancer treatments are challenged by the plasticity of cancer cells, largely influenced by chromosomal instability (CIN) leading to variations in karyotype known as tumor-specific aneuploidy, which in turn, leads to intra-tumor cellular heterogeneity (TH). Cells with certain chromosomal defects often survive treatment and the growth-associated states of TH persist in recurrent tumors. Modulation of the CIN rate seems to reside within the tumor itself. In an attempt to develop a therapy targeting cancer plasticity, we studied the possible extracellular control of CIN rate in... Read more
    This article belongs to the Special Issue Intra-Tumour Genetic Heterogeneity
    J Cancer Metastasis Treat 2018;4:41. | doi:10.20517/2394-4722.2018.16
    Published on: 2 Aug 2018  | Viewed:449  | Downloaded:141
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  • Review|Open Access

    Robotic gastrectomy for gastric cancer

    Masanori Tokunaga, Masahiro Watanabe, Shizuki Sugita, Akiko Tonouchi, Akio Kaito, Takahiro Kinoshita
    Robotic gastrectomy (RG) is increasingly performed, particularly in East Asia. With articulated devices, surgeons are able to perform every procedure more comfortably and meticulously, which makes RG ideal from the surgeon’s standpoint. However, it is still unclear whether it is a suitable treatment strategy from the patient’s viewpoint, due to the lack of solid evidence obtained from randomized controlled trials. The feasibility of RG has been demonstrated in many retrospective comparative studies, which showed similar trends, including relatively less estimated blood loss and longer... Read more
    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment
    J Cancer Metastasis Treat 2018;4:40. | doi:10.20517/2394-4722.2017.80
    Published on: 30 Jul 2018  | Viewed:466  | Downloaded:119
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  • Review|Open Access

    Molecular mechanism of peritoneal dissemination in gastric cancer

    Qing-Jiang Hu, Shuhei Ito, Kazuyoshi Yanagihara, Koshi Mimori
    Peritoneal dissemination (PD) is the most common cause of metastasis in gastric cancer (GC). Because there are no standard treatments for PD, it is associated with a poor prognosis. Although clinicians have performed intraperitoneal chemotherapy for GC with PD, the outcome remains unsatisfactory. Therefore, the development of novel treatments and diagnostic tools for PD is expected to improve the prognosis of GC patients with PD. Notably, it is essential to elucidate the molecular mechanisms involved in the development of PD in GC. In this review, the molecular mechanisms of PD (three... Read more
    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment
    J Cancer Metastasis Treat 2018;4:39. | doi:10.20517/2394-4722.2018.08
    Published on: 26 Jul 2018  | Viewed:494  | Downloaded:156
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  • Review|Open Access

    Laparoscopic personalized function-preserving gastrectomy with sentinel node mapping for early-stage gastric cancer

    Hiroya Takeuchi, Yuko Kitagawa
    Laparoscopic gastrectomy is considered as an indispensable option between endoscopic resection and standard gastrectomy with open laparotomy for patients with early-stage gastric cancer. However, the extent of gastrectomy and remnant gastric function may affect patients’ quality of life (QOL) after surgery. Therefore, function-preserving gastrectomy in addition to laparoscopic surgery could be considered in patients with early-stage gastric cancer. A prospective multicenter trial and meta-analyses of sentinel node (SN) mapping and biopsy for early-stage gastric cancer have demonstrated... Read more
    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment
    J Cancer Metastasis Treat 2018;4:38. | doi:10.20517/2394-4722.2017.83
    Published on: 23 Jul 2018  | Viewed:375  | Downloaded:141
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  • Original Article|Open Access

    New insights into the role of intra-tumor genetic heterogeneity in carcinogenesis: identification of complex single gene variance within tumors

    Bruce Gottlieb, Farbod Babrzadeh, Kathleen Klein Oros, Carlos Alvarado, Chunlin Wang, Baback Gharizadeh, Mark Basik, Celia M.T. Greenwood, Lenore K. Beitel, Mark Trifiro
    Aim: Present cancer hypotheses are almost all based on the concept that accumulation of specific driver gene mutations cause carcinogenesis. The discovery of intra-tumor genetic heterogeneity (ITGH), has resulted in this hypothesis being modified by assuming that most of these ITGH mutations are in passenger genes. In addition, accumulating ITGH data on driver gene mutations have revealed considerable genotype/phenotype disconnects. This study proposes to investigate this disconnect by examining the nature and degree of ITGH in breast tumors. Methods: ITGH was examined in tumors using next... Read more
    This article belongs to the Special Issue Intra-Tumour Genetic Heterogeneity
    J Cancer Metastasis Treat 2018;4:37. | doi:10.20517/2394-4722.2018.26
    Published on: 19 Jul 2018  | Viewed:559  | Downloaded:76
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  • Review|Open Access

    Circulating microRNAs as a liquid biopsy: a next-generation clinical biomarker for diagnosis of gastric cancer

    Shuhei Komatsu, Jun Kiuchi, Taisuke Imamura, Daisuke Ichikawa, Eigo Otsuji
    Accumulating evidence has suggested the potential clinical utility of novel body fluid biomarkers, or “liquid biopsy”, using circulating tumor cells and cell-free nucleic acids from cancer patients. Noninvasive and reproducible, liquid biopsy could provide the basis for individualized therapeutic strategies by identifying genetic and epigenetic aberrations that are closely associated with cancer initiation and progression. MicroRNAs (miRNAs) are short noncoding RNAs that post-transcriptionally regulate gene expression. They also play important roles in various physiological and... Read more
    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment
    J Cancer Metastasis Treat 2018;4:36. | doi:10.20517/2394-4722.2017.58
    Published on: 18 Jul 2018  | Viewed:375  | Downloaded:143
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  • Review|Open Access

    Current trends in gastric cancer treatment in Europe

    Satoshi Kamiya, Ioannis Rouvelas, Mats Lindblad, Magnus Nilsson
    Gastric cancer is one of the major causes of cancer-related deaths, despite the gradual decrease of its incidence in the West. Minimally invasive procedures, such as endoscopic resection and laparoscopic gastrectomy, have been successfully introduced in European high-volume centres, in the treatment of early gastric cancer. Regarding advanced, localized gastric cancer a number of prospective trials have been completed in search of better therapeutic options, aiming to optimize the efficacy vs. adverse effect ratio. From the results of these prospective randomized trials, the therapeutic... Read more
    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment
    J Cancer Metastasis Treat 2018;4:35. | doi:10.20517/2394-4722.2017.76
    Published on: 17 Jul 2018  | Viewed:755  | Downloaded:217
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  • Systematic Review|Open Access

    Surgical treatment of stage IV gastric cancer: is it worthwhile?

    Ilaria Pergolini, Paolo Ciano, Gianluca Guercioni, Marco Catarci
    Aim: To analyze clinical features and survival outcomes of patients with surgically-treated stage IV gastric cancer, in order to evaluate the suitability of surgery in these patients. Methods: We performed a systematic literature search using PubMed, MEDLINE, and Embase on October 9th, 2017. Survival outcomes data were collected. Results: The original search returned 2434 papers. Thirty-nine studies were included in the final review, of which 26 evaluated liver metastasis resection, four pulmonary metastasis resections and nine palliative gastrectomies. In total 933 patients underwent... Read more
    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment
    J Cancer Metastasis Treat 2018;4:33. | doi:10.20517/2394-4722.2017.84
    Published on: 17 Jul 2018  | Viewed:522  | Downloaded:117
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  • Case Report|Open Access

    Necrotizing fasciitis as a complication of taxanes: a case report

    Nasser Mohammed Amer, Rabia Niaz
    Necrotizing fasciitis is a rare complication of chemotherapy, however, few reports were published as a specific complication of taxanes. We are reporting this rare complication of a lady who was treated with taxanes as an adjuvant therapy for her breast cancer who was referred to us from the medical department and turned out to be necrotizing fasciitis in her right thigh. We are also presenting the literature review of this type of complication. Read more
    J Cancer Metastasis Treat 2018;4:34. | doi:10.20517/2394-4722.2018.09
    Published on: 17 Jul 2018  | Viewed:328  | Downloaded:25
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  • Review|Open Access

    Circulating tumor cells in gastric cancer

    Kenichi Nakamura, Masaaki Iwatsuki, Junji Kurashige, Takatsugu Ishimoto, Yoshifumi Baba, Yuji Miyamoto, Naoya Yoshida, Masayuki Watanabe, Hideo Baba
    Circulating tumor cells (CTCs) have received a lot of attention as a novel biomarker for cancer research in past decades. CTCs infiltrate the bloodstream derived from the primary tumor, and are significantly involved in cancer metastasis and recurrence. Although clinical applications have been challenging owing to the difficulties of CTC identification, recent development of technology for specific enrichment and detection of CTCs contributes to diagnosis and treatment. Furthermore, CTC analyses will shed new light on the biological mechanisms of cancer progression and metastasis. A number... Read more
    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment
    J Cancer Metastasis Treat 2018;4:32. | doi:10.20517/2394-4722.2017.78
    Published on: 5 Jul 2018  | Viewed:520  | Downloaded:184
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  • Review|Open Access

    Update on targeted therapy and immune therapy for gastric cancer, 2018

    Yuki Kiyozumi, Masaaki Iwatsuki, Kohei Yamashita, Yuki Koga, Naoya Yoshida, Hideo Baba
    Gastric cancer (GC) remains one of the most common cancers and serious health problems worldwide. For unresectable or metastatic advanced gastric cancer, chemotherapy treatment is first selected. Although chemotherapy has improved survival in patients with advanced gastric cancer (AGC), the prognosis of these patients remains poor. In recent years, some therapies targeting biological molecules have been reported to prolong the survival of patients with AGC. Since trastuzumab, a monoclonal antibody that targets HER2, was established as standard therapy for unresectable GC in a HER2-positive... Read more
    This article belongs to the Special Issue Reviews of Gastric Cancer Metastasis and Treatment
    J Cancer Metastasis Treat 2018;4:31. | doi:10.20517/2394-4722.2017.77
    Published on: 28 Jun 2018  | Viewed:1441  | Downloaded:230
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Journal of Cancer Metastasis and Treatment ISSN 2454-2857 (Online), ISSN 2394-4722 (Print)
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